Use of derivatives of pentaphyrine as antimicrobial and disinfectant agents
AssigneeUniversità degli Studi di Udine
InventorsRosalisa Fedele, Clara Comuzzi, Giada Rossi, Daniele Goi
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Abstract
The invention relates to the use of 20-(4-carboxyphenyl)-2,13-dimethyl-3,12-diethyl-[22] pentaphyrine as antibacterial agent in photodynamic treatment. This expanded porphyrin derivatized in position 4 with a carboxyphenyl group proved very active after photo-oxidation both against S. aureus and E. hirae. Its high antibacterial activity and its low toxicity make this pentaphyrine particularly useful as antimicrobial agent both for photodynamic therapy against bacterial infections and in the disinfection of microbiologically contaminated liquids.
Claims3
A method of treatment of microbial infections by photodynamic therapy comprising the administration in a subject in a need thereof an effective amount of at least one pentaphyrine selected from the group consisting of 20-(4-carboxyphenyl)-2,13-dimethyl-3,12-diethyl-[22] pentaphyrine, its metallated derivatives and salts thereof.
A method of disinfection comprising the treatment with an effective amount of at least one pentaphyrine selected from the group consisting of 20-(4-carboxyphenyl)-2,13-dimethyl-3,12-diethyl-[22] pentaphyrine, its metallated derivatives and salts thereof of, a microbiologically contaminated liquid.
Dependencies are inferred from the claim text.