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US 8,940,764 B2Granted
Compositions and methods of treating retinal disease
AssigneeAldexa Therapeutics, Inc.
InventorsThomas A. Jordan, John E. Dowling, John Clifford Chabala
Life of this patent
Estimating the term…
Abstract
Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed.
Claims15
A compound of formula IIIa:
- or a pharmaceutically acceptable salt thereof, wherein:
- A is
- B is a halogen atom, hydroxyl, carbamoyl, aryl or amino;
- p is 0, 1, 2, or 3;
- D is unbranched lower alkyl;
- L is a single bond or CH2;
- and
- X, Y, and Z are each, independently, N, NH, O, S, CB, CH, or absent, such that at least one of X, Y, and Z is N or NH;
- wherein X, Y, and Z and the carbon atoms to which they are attached form a 5- or 6-membered optionally substituted heterocyclic ring.
6 more elements
A compound, which is
- or a pharmaceutically acceptable salt thereof.
A compound, which is
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.