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US 8,940,762 B2Granted
Methods for treating pain
AssigneeAbbVie Inc.
InventorsChih-Hung Lee, Michael R. Schrimpf, Timothy A. Esbenshade, Chang Z. Zhu
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Abstract
The present invention is directed to methods of treating pain by administering a therapeutically effective amount of an α7 nAChR ligand or a pharmaceutically acceptable salt thereof, to a mammal in need of treatment thereof and to pharmaceutical compositions comprising such a compound or salt.
Claims4
A method for treating osteoarthritis pain in a patient comprising:
- administering a therapeutically effective amount of an α7 nAChR ligand to the patient, wherein the α7 nAChR ligand is a compound of formula (I),
- or a pharmaceutically acceptable salt, ester, or amide thereof, wherein
- n is 2;
- A is N;
- R is hydrogen or alkyl;
- L is selected from the group consisting of O and —N(Ra)—;
- Ar1 is pyridinyl;
- Ar2 is
- wherein Z1, Z2, Z3 and Z4 are each carbon;
- Rb is selected from the group consisting of hydrogen and alkyl;
- R6 is selected from the group consisting of hydrogen, alkyl, and haloalkyl;
- R7 is hydrogen;
- and
- Ra is hydrogen.
11 more elements
A method for treating osteoarthritis pain in a patient, the method comprising administering a therapeutically effective amount of an α7 nAChR ligand selected from:
- 5-{5-[(endo)-8-Azabicyclo[3.2.1]octan-3-yloxy]pyridin-2-yl}-1H-indole;
- 4-{5-[(endo)-8-Azabicyclo[3.2.1]octan-3-yloxy]pyridin-2-yl}-1H-indole;
- 5-{5-[(exo)-8-Azabicyclo[3.2.1]octan-3-yloxy]pyridin-2-yl}-1H-indole;
- 4-{5-[(exo)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yloxy]-pyridin-2-yl}-1H-indole;
- and
- 5-{6-[(endo)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yloxy]-pyridin-3-yl}-1H-indole, or
- a pharmaceutically acceptable salt, solvate, ester or amide thereof.
4 more elements
Dependencies are inferred from the claim text.