Pyrazolo pyridine derivatives as NADPH oxidase inhibitors

A method for the treatment of a patient suffering from a disease or condition selected from diabetic nephropathy, liver fibrosis, alcohol induced fibrosis, steatosis or non-alcoholic steatohepatitis, cancer, hypertension, atherosclerosis, pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary diseases (COPD), Alzheimer's disease, diabetes, asthma, hearing loss and balance problems in response to ototoxic drugs, vascular injuries after balloon surgery, inflammation, cardiovascular complications of type 1 or type II diabetes, intimal hyperplasia, coronary heart disease, cerebral, coronary or arterial vasospasm, endothelial dysfunction, inflammatory bowel disease, Crohn's disease, multiple sclerosis, or pain, the method comprising administering a pyrazolo pyridine derivative according to Formula (I):

• wherein G1 is selected from —C(O)—R1 and —(CH2)n—C(O)—R4;
• R1 is selected from H;
• optionally substituted amino;
• optionally substituted alkoxy;
• optionally substituted alkoxy C1-C6 alkyl;
• —NR2R3;
• optionally substituted C1-C6 alkyl;
• optionally substituted C2-C6 alkenyl;
• optionally substituted C2-C6 alkynyl;
• optionally substituted aryl;
• optionally substituted C1-C6 alkyl aryl;
• optionally substituted aryl C1-C6 alkyl;
• optionally substituted heteroaryl;
• optionally substituted C1-C6 alkyl heteroaryl;
• optionally substituted heteroaryl C1-C6 alkyl;
• optionally substituted C2-C6 alkenyl aryl;
• optionally substituted aryl C2-C6 alkenyl;
• optionally substituted C2-C6 alkenyl heteroaryl;
• optionally substituted heteroaryl C2-C6 alkenyl;
• optionally substituted C3-C8-cycloalkyl;
• optionally substituted heterocycloalkyl;
• optionally substituted C1-C6 alkyl C3-C8-cycloalkyl;
• optionally substituted C3-C8-cycloalkyl C1-C6 alkyl;
• optionally substituted C1-C6 alkyl heterocycloalkyl and optionally substituted heterocycloalkyl C1-C6 alkyl;
• R2 and R3 independently selected from H, optionally substituted C1-C6 alkyl;
• optionally substituted C2-C6 alkenyl;
• optionally substituted C2-C6 alkynyl;
• optionally substituted aryl;
• optionally substituted C1-C6 alkyl aryl;
• optionally substituted aryl C1-C6 alkyl;
• optionally substituted heteroaryl;
• C1-C6 alkyl heteroaryl;
• optionally substituted heteroaryl C1-C6 alkyl;
• optionally substituted C2-C6 alkenyl aryl;
• optionally substituted aryl C2-C6 alkenyl;
• optionally substituted C2-C6 alkenyl heteroaryl;
• optionally substituted heteroaryl C2-C6 alkenyl;
• optionally substituted C3-C8-cycloalkyl;
• optionally substituted heterocycloalkyl;
• optionally substituted C1-C6 alkyl C3-C8-cycloalkyl;
• optionally substituted C3-C8-cycloalkyl C1-C6 alkyl;
• optionally substituted C1-C6 alkyl heterocycloalkyl and optionally substituted heterocycloalkyl C1-C6 alkyl or —NR2R3 can form together a ring selected from optionally substituted heteroaryl or optionally substituted heterocycloalkyl;
• R4 is selected from H;
• optionally substituted alkoxy;
• optionally substituted alkoxy C1-C6 alkyl;
• optionally substituted C1-C6 alkyl;
• optionally substituted C2-C6 alkenyl;
• optionally substituted C2-C6 alkynyl;
• optionally substituted aryl;
• optionally substituted C1-C6 alkyl aryl;
• optionally substituted aryl C1-C6 alkyl;
• optionally substituted heteroaryl;
• optionally substituted C1-C6 alkyl heteroaryl;
• optionally substituted heteroaryl C1-C6 alkyl;
• optionally substituted C2-C6 alkenyl aryl;
• optionally substituted aryl C2-C6 alkenyl;
• optionally substituted C2-C6 alkenyl heteroaryl;
• optionally substituted heteroaryl C2-C6 alkenyl;
• optionally substituted C3-C8-cycloalkyl;
• optionally substituted heterocycloalkyl;
• optionally substituted C1-C6 alkyl C3-C8-cycloalkyl;
• optionally substituted C3-C8-cycloalkyl C1-C6 alkyl;
• optionally substituted C1-C6 alkyl heterocycloalkyl and optionally substituted C1-C6 alkyl;
• n is an integer selected from 1 to 5;
• G2 is selected from H;
• optionally substituted C1-C6 alkyl;
• optionally substituted C2-C6 alkenyl;
• optionally substituted C2-C6 alkynyl;
• optionally substituted aryl;
• optionally substituted C1-C6 alkyl aryl;
• optionally substituted aryl C1-C6 alkyl;
• optionally substituted heteroaryl;
• optionally substituted alkyl heteroaryl;
• optionally substituted heteroaryl C1-C6 alkyl;
• optionally substituted C2-C6 alkenyl aryl;
• optionally substituted aryl C2-C6 alkenyl;
• optionally substituted C2-C6 alkenyl heteroaryl;
• optionally substituted heteroaryl C2-C6 alkenyl;
• optionally substituted C3-C8-cycloalkyl;
• optionally substituted heterocycloalkyl;
• optionally substituted alkyl C3-C8-cycloalkyl;
• optionally substituted C3-C8-cycloalkyl C1-C6 alkyl;
• optionally substituted C1-C6 alkyl heterocycloalkyl and optionally substituted heterocycloalkyl C1-C6 alkyl;
• G3 is selected from H;
• optionally substituted amino;
• optionally substituted aminoalkyl;
• optionally substituted aminocarbonyl;
• optionally substituted alkoxy;
• optionally substituted alkoxy C1-C6 alkyl;
• optionally substituted carbonyl;
• optionally substituted C1-C6 alkyl;
• optionally substituted C2-C6 alkenyl;
• optionally substituted C2-C6 alkynyl;
• optionally substituted aryl;
• optionally substituted aryl C1-C6 alkyl;
• optionally substituted heteroaryl;
• optionally substituted C1-C6 alkyl heteroaryl;
• optionally substituted heteroaryl C1-C6 alkyl;
• optionally substituted C2-C6 alkenyl aryl;
• optionally substituted aryl C2-C6 alkenyl;
• optionally substituted C2-C6 alkenyl heteroaryl;
• optionally substituted heteroaryl C2-C6 alkenyl;
• optionally substituted C3-C8-cycloalkyl;
• optionally substituted heterocycloalkyl;
• optionally substituted C1-C6 alkyl C3-C8-cycloalkyl;
• optionally substituted C3-C8-cycloalkyl C1-C6 alkyl;
• optionally substituted C1-C6 alkyl heterocycloalkyl and optionally substituted heterocycloalkyl C1-C6 alkyl;
• G4 is selected from H;
• optionally substituted acyl;
• optionally substituted acyl amino;
• optionally substituted acyl C1-C6 alkyl;
• optionally substituted C1-C6 alkyl;
• optionally substituted C2-C6 alkenyl;
• optionally substituted C2-C6 alkynyl;
• optionally substituted aryl;
• optionally substituted C1-C6 alkyl aryl;
• optionally substituted aryl C1-C6 alkyl;
• optionally substituted heteroaryl;
• optionally substituted C1-C6 alkyl heteroaryl;
• optionally substituted heteroaryl C1-C6 alkyl;
• optionally substituted C2-C6 alkenyl aryl;
• optionally substituted aryl C2-C6 alkenyl;
• optionally substituted alkenyl heteroaryl;
• optionally substituted heteroaryl C2-C6 alkenyl;
• optionally substituted C3-C8-cycloalkyl;
• optionally substituted heterocycloalkyl;
• optionally substituted C1-C6 alkyl C3-C8-cycloalkyl;
• optionally substituted C3-C8-cycloalkyl C1-C6 alkyl;
• optionally substituted C1-C6 alkyl heterocycloalkyl and optionally substituted heterocycloalkyl C1-C6 alkyl;
• G5 is selected from H;
• optionally substituted C1-C6 alkyl;
• optionally substituted C2-C6 alkenyl;
• optionally substituted C2-C6 alkynyl;
• optionally substituted aryl;
• optionally substituted C1-C6 alkyl aryl;
• optionally substituted aryl C1-C6 alkyl;
• optionally substituted heteroaryl;
• optionally substituted C1-C6 alkyl heteroaryl;
• optionally substituted heteroaryl C1-C6 alkyl;
• optionally substituted C2-C6 alkenyl aryl;
• optionally substituted aryl C2-C6 alkenyl;
• optionally substituted C2-C6 alkenyl heteroaryl;
• optionally substituted heteroaryl C2-C6 alkenyl;
• optionally substituted C3-C8-cycloalkyl;
• optionally substituted heterocycloalkyl;
• optionally substituted C1-C6 alkyl C3-C8-cycloalkyl;
• optionally substituted C3-C8-cycloalkyl C1-C6 alkyl;
• optionally substituted C1-C6 alkyl heterocycloalkyl and optionally substituted heterocycloalkyl C1-C6 alkyl;
• or a tautomer, geometrical isomer, enantiomer, diastereomer, racemate or pharmaceutically acceptable salts thereof, to a patient in need of treatment of said disease or condition.