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US 8,940,758 B2Granted
Fused heterocyclic compounds
AssigneeTakeda Pharmaceutical Company Limited
InventorsTakahiko Taniguchi, Masato Yoshikawa, Kasei Miura, Tomoaki Hasui, Eiji Honda, Keisuke Imamura, Makoto Kamata, Haruhi Ando
Life of this patent
Estimating the term…
Abstract
The present invention provides a compound which has the effect of PDE inhibition, and which is useful as an agent for preventing or treating schizophrenia. The compound is represented by the formula (I): wherein the symbols are defined in the specification.
Claims17
A method for treating obesity, drug addiction, or attention-deficit/hyperactivity disorder in a mammal, which comprises administering an effective amount of a compound represented by the formula (I) to the mammal:
- wherein
- ring A represents an optionally substituted 6-membered ring,
- any one or two of from Z1 to Z4 represent —N═, and the others represent —CH═;
- the nitrogen atom of —N═ for Z1 to Z4 may be oxidized;
- Y represents an oxygen atom, a sulfur atom, an optionally substituted methylene group or —NRc—;
- Rc represents a hydrogen atom, or a substituent;
- and
- R represents
- (1) a group represented by the formula:
- wherein
- R1 represents a phenyl group or 5- to 10-membered heterocyclic group, each of which is optionally substituted;
- L represents a sulfur atom, an oxygen atom, an optionally substituted methylene group, —CO—, —NRa—, —CH2O—, —OCH2—, —NRaCOO—, —OCONRa—, —NRaCONRb—, —NRaCOCH2—, —CH2CONRa—, —NRaCO—, —CONRa—,
- Ra and Rb are the same or different and each represents a hydrogen atom, or an optionally substituted C1-6 alkyl group, or
- L and R1 in combination optionally form an optionally substituted bi- or tri-cyclic fused heterocyclic group;
- and
- ring B1 represents a benzene ring, a pyridine ring, a pyrimidine ring, a pyrazine ring or a pyridazine ring, each of which is optionally substituted;
- or
- (2) a group represented by the formula:
- wherein
- R2 represents a phenyl group or 5- to 10-membered heterocyclic group, each of which is optionally substituted;
- and
- the partial structure of the formula:
- is
- wherein
- Rx1 and Rx2 are the same or different and each is a hydrogen atom or an optionally substituted C1-6 alkyl group,
- Rx3 and Rx5 are each a hydrogen atom or an optionally substituted C1-6 alkyl group, and
- the ring-constituting atom(s) of ring B2 and ring D optionally further have substituent(s),
- or a salt thereof.
25 more elements
Dependencies are inferred from the claim text.