Back to results
US 8,940,743 B2Granted
Piperidin-4-yl-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists
AssigneeJanssen Pharmaceutica NV
InventorsMarcel Frans Leopold De Bruyn, Gregor James MacDonald, Ludo Edmond Josephine Kennis, Xavier Jean Michel Langlois, Frans Alfons Maria Van Den Keybus, Yves Emiel Maria Van Roosbroeck
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
Claims8
A compound of formula (I)
- or a pharmaceutically acceptable salt thereof, or a stereoisomeric form thereof, wherein
- R is hydrogen or C1-6alkyl;
- R1 is phenyl;
- phenyl substituted with 1, 2 or 3 substituents each independently selected from the group consisting of hydrogen, halo, cyano, C1-4 alkyl, C1-4alkyloxy, perfluoroC1-4alkyl, diC1-4alkylamino;
- thienyl;
- thienyl substituted with 1 or 2 substituents selected from the group consisting of halo and C1-4alkyl;
- C3-8cycloalkyl;
- or C5-7cycloalkenyl;
- R2 is hydrogen or C1-6alkyl;
- R3 is halo, C1-4alkyl or perfluoroC1-4alkyl;
- and
- R4 and R5 each independently are hydrogen or halo.
9 more elements
Dependencies are inferred from the claim text.