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US 8,940,739 B2Granted
Compound of a reverse-turn mimetic and a production method and use therefor
AssigneeJw Pharmaceutical Corporation
InventorsJae-Uk Chung, Mi-Jung Kim, Yong-Sil Lee, Sang-Ho Ma, Young-Seok Cho, Sang-Hak Lee, Young-Jun Na, Myoung-Joo Kang, Woul-Seong Park
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Abstract
This invention relates to novel compounds of reverse-turn mimetics, having pyrazino-triazinone as a basic framework, and a method of preparing the same, and the use thereof to treat diseases such as cancer, in particular, acute myeloid leukemia.
Claims8
A compound represented by Formula I below or a pharmaceutically acceptable salt thereof:
- wherein Ra is C1-C6 alkyl group, C2-C6 alkenyl group, or C2-C6 alkynyl group;
- wherein R1 is H, C1-C12 alkyl group or substituted C1-C12 alkyl group;
- R2 is H, C1-C30 alkyl group, C3-C10 cycloalkyl group, amino group, C1-C30 alkoxy group, benzyl group,
- and wherein the C1-C30 alkyl group, the C3-C10 cycloalkyl group, the amino group, the C1-C30 alkoxy group, and the benzyl group may be substituted with at least one Rq,
- R1 and R2 may be joined together to form an aliphatic ring, an aliphatic hetero ring, an aromatic ring, or an aromatic hetero ring or to form a spiro bond, in which the rings may optionally have at least one substituent;
- R3 is C3-C20 acyl group, substituted C3-C20 acyl group, cyano group or sulfonyl group;
- R4 is H, substituted or unsubstituted amino group, C1-C20 acyl group or substituted C1-C20 acyl group;
- and
- Rp is H or a prodrug functional group, wherein the prodrug functional group is —PO3H2, —HPO3−Na+, —PO32−Na2+, —PO32−K2+, —PO32−Mg2+, PO32−Ca2+,
- wherein Rq is H, at least one C1-C10 alkyl, substituted C1-C10 alkyl, C1-C10 cycloalkyl, substituted C1-C10 cycloalky, amino, substituted amino, C1-C10 alkoxy, substituted C1-C10 alkoxy, halogen, —OH, benzyl, substituted benzyl, acyl, substituted acyl, phenyl, substituted phenyl, butyl oxy carbonyl (BOC),
- wherein X is H, at least one C1-C10 alkyl, substituted C1-C10 alkyl, acyl, C3-C10 cycloalkyl, C1-C10 alkoxy, phenyl, substituted phenyl, benzyl, substituted benzyl, a C1-C10 hetero aromatic ring, C3-C10 heterocycloalkyl, substituted C3-C10 heterocycloalkyl, amino, substituted amino, or —OH,
- wherein the C3-C10 heterocycloalkyl and the substituted C3-C10 heterocycloalkyl contain one or two heteroatoms wherein each heteroatom is independently selected from N and O, and wherein the substituted C3-C10 heterocycloalkyl is methyl substituted C3-C10 heterocycloalkyl, methoxy substituted C3-C10 heterocycloalkyl, or
- substituted C3-C10 heterocycloalkyl.
10 more elements
Dependencies are inferred from the claim text.