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US 8,940,738 B2Granted
Pyrimidone compounds
AssigneeMitsubishi Tanabe Pharma Corporation
InventorsDaiki Sakai, Kazuki Nakayama, Kazutoshi Watanabe
Life of this patent
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Abstract
A pyrimidone derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof: wherein X represents hydrogen atom and Y represents hydroxyl group, or X represents fluorine atom and Y represents hydrogen atom; R1 represents a C1-6 alkyl group; R2 represents a morpholin-4-yl group which may be substituted, or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).
Claims5
A compound represented by general formula (I)
- wherein X represents a hydrogen atom;
- Y represents a hydroxyl group;
- R1 represents a C1-6 alkyl group;
- and
- R2 is a group represented by the following formula (iii):
- wherein Z represents an oxygen atom;
- R5a, R5b, and R5d each independently represents a hydrogen atom;
- and
- R5c represents a phenyl group substituted by 1,2,4-oxadiazolyl which may be substituted by a C1-6 alkyl group,
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.