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US 8,940,731 B2Granted
Substituted pyridyl amide compounds as modulators of the histamine H3 receptor
AssigneeJanssen Pharmaceutica NV
InventorsJohn M. Keith, Michael A. Letavic, Kiev S. Ly, Neelakandha S. Mani, John E. Mills, Chennagiri R. Pandit, Frank J. Villani, Hua Zhong
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Abstract
Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
Claims5
A compound of Formula (II):
- wherein
- R1 is —C1-4alkyl or saturated monocyclic cycloalkyl;
- each R3 substituent is independently selected from the group consisting of:
- halo, —C1-4alkyl, —OH, —OC1-4alkyl, —SC1-4alkyl, —CN, —CONRdRe, and —NO2;
- where Rd and Re are each independently —H or —C1-4alkyl;
- and
- n is 0, 1, 2, or 3;
- or a pharmaceutically acceptable salt thereof.
5 more elements
A compound of Formula (III):
- wherein
- R1 is —C1-4alkyl or saturated monocyclic cycloalkyl;
- each R3 substituent is independently selected from the group consisting of:
- halo, —C1-4alkyl, —OH, —OC1-4alkyl, —SC1-4alkyl, —CN, —CONRdRe, and —NO2;
- where Rd and Re are each independently —H or —C1-4alkyl;
- and
- n is 0, 1, 2, or 3;
- or a pharmaceutically acceptable salt thereof.
5 more elements
A compound selected from the group consisting of:
- (4-Ethyl-[1,4]diazepan-1 -yl)- [6-(4-fluoro-phenoxy)-pyridin-3-yl]-methanone;
- and
- [6-(4-Fluoro-phenoxy)-pyridin-3-yl]-(4-methyl-[1,4]diazepan-1-yl)-methanone;
- and pharmaceutically acceptable salts thereof.
1 more element
Dependencies are inferred from the claim text.