Benzazepine compound
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsKeizo Kan, Tadaaki Ohtani
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Abstract
An object of the present invention is to provide a novel benzazepine compound or a salt thereof, which has excellent vasopressin antagonistic activity. The benzazepine compound or a salt thereof of the present invention is represented by Formula (1): wherein R1, R2 and R5 may be the same or different and each represents H or D; and R3 and R4 each represents a C1-6 alkyl group, a C1-6 deuteroalkyl group, or a C1-6 perdeuteroalkyl group.
Claims8
A benzazepine compound selected from the group consisting of:
- (1) N-(4-(7-chloro-5-hydroxy-2,3,4-trihydro-5-deutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide,
- (2) N-(4-(7-chloro-2,3-dihydro-5-hydroxy-4,4,5-trideutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide,
- (3) N-(4-(7-chloro-5-hydroxy-2,2-dideutero-3,4,5-trihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide, and
- (4) N-(4-(7-chloro-5-hydroxy-2,2,4,4,5-pentadeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide,
- or a salt thereof.
A benzazepine compound, which is (3) N-(4-(7-chloro-5-hydroxy-2,2-dideutero-3,4,5-trihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide or a salt thereof.
A benzazepine compound, which is (4) N-(4-(7-chloro-5-hydroxy-2,2,4,4,5-pentadeutero-1H-benzo[b]azepone-1-carbonyl)-3-methylphenyl)-2-methylbenzamide or a salt thereof.
Dependencies are inferred from the claim text.