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US 8,940,718 B2Granted
Antiviral compounds
AssigneeGilead Pharmasset LLC
InventorsElizabeth M. Bacon, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, Evan S. Krygowski, John O. Link, James Taylor, Chinh Viet Tran, Teresa Alejandra Trejo Martin, Zheng-Yu Yang, Sheila Zipfel
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Abstract
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Claims28
A compound of formula (I):
- E1a-V1a—C(═O)—P1a—W1a—P1b—C(═O)—V1b-E1b (I)
- wherein
- W1a is
- and W1a is optionally substituted with one or more groups independently selected from halo, alkyl, haloalkyl, or cyano;
- Y5 is —O—CH2—, or —CH2—O—;
- X5 is —CH═CH—;
- E1a is —N(H)(alkoxycarbonyl), —N(H)(cycloalkylcarbonyl)
- or —N(H)(cycloalkyloxycarbonyl);
- or E1a-V1a taken together are R9a;
- E1b is —N(H)(alkoxycarbonyl), —N(H)(cycloalkylcarbonyl)
- or —N(H)(cycloalkyloxycarbonyl);
- or E1b-V1b taken together are R9b;
- V1a and V1b are each independently selected from:
- P1a is selected from:
- P1b is selected from:
- and
- R9a and R9b are each independently:
- or a pharmaceutically acceptable salt thereof.
15 more elements
Dependencies are inferred from the claim text.