Bicyclic heteroaryl compounds as GPR119 modulators

A compound of formula IIa:

• or an enantiomer, diastereomer, tautomer or salt thereof wherein:
• D is O or S;
• G is CR5 or N;
• J is CH or N;
• W is —S(═O)2—R1, —C(═O)—R1, —C(═O)—O—R1, or a 4- to 10-membered heteroaryl, which contains 1-4 heteroatoms selected from N, O, and S and may be optionally substituted with one or more R20's;
• L is —CR1aR1a—, or —O—;
• provided that L is —O— when A is
• R1a, at each occurrence, is independently hydrogen or (C1-C8)alkyl;
• R1 is (C1-C6)-alkyl, (C2-C6)-alkenyl, (C3-C12)-cycloalkyl, (C6-10)aryl, a 4- to 10-membered heteroaryl, which contains 1-4 heteroatoms selected from N, O, and S;
• or a 4- to 10-membered heterocyclo, which contains 1-4 heteroatoms selected from N, O, and S;
• all of which may be optionally substituted with one or more R20's;
• R4 is (C1-C6)-alkyl;
• which may be optionally substituted with one or more substituents selected from the group consisting of:
• halo, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C12)-cycloalkyl, (C1-C6)-alkyloxy, cyano, nitro, —COOH, —CO(C1-C6)-alkyl, —CO2(C1-C6)-alkyl, —CONR18R19, —NR18R19, —O(C═O)—(C1-C6)-alkyl, —O(C═O)NR18R19, —(C1-C6)-alkylCOOH, —(C1-C6)-alkylOH, —(C1-C6)-alkyl(NH2)COOH, —(C1-C6)-alkylCONR18R19, —(C1-C6)-alkyl-CO2(C1-C6)-alkyl, (C6-10)aryl, heteroaryl, heterocyclo, dioxo-substituted heteroaryl, halo(C1-C6)alkyl, and halo(C1-C6)alkyloxy;
• and wherein any heteroaryl and heterocyclo contains 4- to 10-members and 1-4 heteroatoms selected from N, O, and S;
• or
• R4 is (C2-C6)-alkenyl, (C2-C6)-alkynyl, —CO(C1-C6)-alkyl, —CO(C3-C12)-cycloalkyl, —CO(C6-10)aryl, —CO-heteroaryl, —CO2(C1-C6)-alkyl, —CO2(C3-C12)-cycloalkyl, —CO2(C6-10)aryl, —SO2(C1-C6)-alkyl, —SO2(C3-C12)-cycloalkyl, —SO2(C6-10)aryl, —SO2-heteroaryl, (C6-10)aryl, heteroaryl or heterocyclo, wherein any alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclo may be optionally substituted with one or more substituents selected from the group consisting of:
• halo, —OH, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C12)-cycloalkyl, (C1-C6)-alkyloxy, cyano, nitro, —COOH, —CO(C1-C6)-alkyl, —CO2(C1-C6)-alkyl, —CONR18R19, —NR18R19, —O(C═O)—(C1-C6)-alkyl, —O(C═O)NR18R19, —(C1-C6)-alkylCOOH, —(C1-C6)-alkylOH, —(C1-C6)-alkyl(NH2)COOH, —(C1-C6)-alkylCONR18R19, —(C1-C6)-alkyl-CO2(C1-C6)-alkyl, (C6-10)aryl, heteroaryl, heterocyclo, dioxo-substituted heteroaryl, halo(C1-C6)alkyl, and halo(C1-C6)alkyloxy;
• and wherein any heteroaryl and heterocyclo contains 4- to 10-members and 1-4 heteroatoms selected from N, O, and S;
• R5, is independently H, halo, —OH or (C1-C6)-alkyl;
• R18 and R19, at each occurrence, are independently hydrogen or (C1-C8)alkyl, wherein the alkyl may be optionally substituted with one or more R20's;
• or R18 and R19 are taken together with the nitrogen to which both are attached to form a 3- to 8-membered ring, which may optionally contain 1-4 heteroatoms selected from N, O, and S and be optionally substituted with one or more R20's;
• R20, at each occurrence, is independently halo, —OH, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, —(C3-C12)-cycloalkyl, (C1-C6)-alkyloxy, cyano, nitro, —COOH, —CO(C1-C6)-alkyl, —CO2(C1-C6)-alkyl, —CONR28R29, —NR28R29,—NR28COR29, —O(C═O)—(C1-C6)-alkyl, —O(C═O)NR28R29, —(C1-C6)-alkylCOOH, —(C1-C6)-alkylOH, —(C1-C6)-alkyl(NH2)COOH, —(C1-C6)-alkylCONR28R29, —(C1-C6)-alkyl-CO2(C1-C6)-alkyl, —O—P(═O)(OR28)2, —O—CR1aR1a—P(═O)(OR28)2, —P(═O)(OR28)2, (C6-10)aryl, (C6-10)aryloxy, —SO3H, —SO2R28, —SO2NR28R29, —NR28—SO2—R29, a 4- to 10-membered heteroaryl, which contains 1-4 heteroatoms selected from N, O, and S;
• or a 4- to 10-membered heterocyclo, which contains 1-4 heteroatoms selected from N, O, and S;
• wherein any alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclo may be optionally substituted with one or more substituents selected from the group consisting of:
• halo, —OH, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-alkyloxy, cyano, nitro, —COOH, —CO(C1-C6)-alkyl, —CO2(C1-C6)-alkyl, —CONR28R29, —NR28R29, —O(C═O)—(C1-C6)-alkyl, —O(C═O)NR28R29, —(C1-C6)-alkylCOOH, —(C1-C6)-alkylOH, —(C1-C6)-alkyl(NH2)COOH, —(C1-C6)-alkylCONR28R29, —(C1-C6)-alkyl-CO2(C1-C6)-alkyl, (C6-10)aryl, a 4- to 10-membered heteroaryl, which contains 1-4 heteroatoms selected from N, O, and S, a 4- to 10-membered heterocyclo, which contains 1-4 heteroatoms selected from N, O, and S;
• halo(C1-C6)alkyl, and halo(C1-C6)alkyloxy;
• and
• R28 and R29, at each occurrence, are independently hydrogen or (C1-C8)alkyl, wherein the alkyl may be optionally substituted with one or more substituents selected from the group consisting of:
• halo, —OH, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-alkyloxy, cyano, nitro, —COOH, —CO(C1-C6)-alkyl, —CO2(C1-C6)-alkyl, —O(C═O)—(C1-C6)-alkyl, —(C1-C6)-alkylCOOH, —(C1-C6)-alkylOH, —(C1-C6)-alkyl(NH2)COOH, —(C1-C6)-alkylCONR28R29, —(C1-C6)-alkyl-CO2(C1-C6)-alkyl, (C6-10)aryl, a 4- to 10-membered heteroaryl, which contains 1-4 heteroatoms selected from N, O, and S, a 4- to 10-membered heterocyclo, which contains 1-4 heteroatoms selected from N, O, and S;
• halo(C1-C6)alkyl, and halo(C1-C6)alkyloxy;
• or R28 and R29 are taken together with the nitrogen to which both are attached to form a 3- to 8-membered ring, which may optionally contain 1-4 heteroatoms selected from N, O, and S, wherein the ring may be optionally substituted with one or more substituents selected from the group consisting of:
• halo, —OH, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-alkyloxy, cyano, nitro, —COOH, —CO(C1-C6)-alkyl, —CO2(C1-C6)-alkyl, —O(C═O)—(C1-C6)-alkyl, —(C1-C6)-alkylCOOH, —(C1-C6)-alkylOH, —(C1-C6)-alkyl(NH2)COOH, —(C1-C6)-alkyl-CO2(C1-C6)-alkyl, (C6-10)aryl, a 4- to 10-membered heteroaryl, which contains 1-4 heteroatoms selected from N, O, and S, a 4- to 10-membered heterocyclo, which contains 1-4 heteroatoms selected from N, O, and S;
• halo(C1-C6)alkyl, and halo(C1-C6)alkyloxy.