Micro-RNA family that modulates fibrosis and uses thereof
AssigneeBoard of Regents, The University of Texas System
InventorsEric N. Olson, Eva van Rooij
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Abstract
The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease.
Claims16
A method of increasing expression of one or more extracellular matrix genes in a subject in need thereof comprising administering to the fibroblast cells of the subject an antisense oligonucleotide comprising a sequence that is at least partially complementary to a miR-29a, miR-29b, and/or miR-29c sequence, wherein the expression of one or more extracellular matrix genes in the fibroblast cells of the subject is increased following administration of the antisense oligonucleotide.
Dependencies are inferred from the claim text.