US 8,940,710 B2 · Human monoclonal antibody

Abstract

The present invention provides an anti-CD81 antibody usable as a pharmaceutical product for human. Specifically, the present invention provides an anti-human CD81 antibody capable of binding to a peptide region consisting of the amino acid sequence of the amino acid numbers 80 to 175 in the amino acid sequence shown in SEQ ID NO:22.

Claims12

Dependent claims

An isolated polynucleotide comprising a nucleotide sequence that encodes a heavy chain variable region and a light chain variable region of an isolated anti-human CD81 antibody capable of binding to a peptide region consisting of the amino acid sequence of the amino acid numbers 80 to 175 in the amino acid sequence of SEQ ID NO:

A combination of an isolated polynucleotide comprising a nucleotide sequence that encodes a heavy chain variable region of an isolated anti-human CD81 antibody, and an isolated polynucleotide comprising a nucleotide sequence that encodes the corresponding light chain variable region of the anti-human CD81 antibody, wherein the anti-human CD81 antibody comprises all 6 complementarity determining regions (CDRs) described in any one of the following groups 1 to 24:

Group 1
(a-1) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-1) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-1) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-1) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-1) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-1) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 2
(a-2) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-2) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-2) a CDR comprising the amino acid sequence of SEQ ID NO:
37,
(d-2) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-2) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-2) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 3
(a-3) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-3) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-3) a CDR comprising the amino acid sequence of SEQ ID NO:
40,
(d-3) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-3) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-3) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 4
(a-4) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-4) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-4) a CDR comprising the amino acid sequence of SEQ ID NO:
43,
(d-4) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-4) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-4) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 5
(a-5) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-5) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-5) a CDR comprising the amino acid sequence of SEQ ID NO:
46,
(d-5) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-5) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-5) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 6
(a-6) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-6) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-6) a CDR comprising the amino acid sequence of SEQ ID NO:
49,
(d-6) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-6) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-6) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 7
(a-7) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-7) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-7) a CDR comprising the amino acid sequence of SEQ ID NO:
52,
(d-7) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-7) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-7) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 8
(a-8) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-8) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-8) a CDR comprising the amino acid sequence of SEQ ID NO:
43,
(d-8) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-8) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-8) a CDR comprising the amino acid sequence of SEQ ID NO:
55
Group 9
(a-9) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-9) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-9) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-9) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-9) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-9) a CDR comprising the amino acid sequence of SEQ ID NO:
61
Group 10
(a-10) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-10) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-10) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-10) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-10) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-10) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 11
(a-11) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-11) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-11) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-11) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-11) a CDR comprising the amino acid sequence of SEQ ID NO:
69, and
(f-11) a CDR comprising the amino acid sequence of SEQ ID NO:
70
Group 12
(a-12) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-12) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-12) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-12) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-12) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-12) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 13
(a-13) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-13) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-13) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-13) a CDR comprising the amino acid sequence of SEQ ID NO:
77,
(e-13) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-13) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 14
(a-14) a CDR comprising the amino acid sequence of SEQ ID NO:
80,
(b-14) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-14) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-14) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-14) a CDR comprising the amino acid sequence of SEQ ID NO:
81, and
(f-14) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 15
(a-15) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-15) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-15) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-15) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-15) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-15) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 16
(a-16) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-16) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-16) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-16) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-16) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-16) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 17
(a-17) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-17) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-17) a CDR comprising the amino acid sequence of SEQ ID NO:
52,
(d-17) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-17) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-17) a CDR comprising the amino acid sequence of SEQ ID NO:
93
Group 18
(a-18) a CDR comprising the amino acid sequence of SEQ ID NO:
98,
(b-18) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-18) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-18) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-18) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-18) a CDR comprising the amino acid sequence of SEQ ID NO:
99
Group 19
(a-19) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-19) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-19) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-19) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-19) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-19) a CDR comprising the amino acid sequence of SEQ ID NO:
99
Group 20
(a-20) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-20) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-20) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-20) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-20) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-20) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 21
(a-21) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-21) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-21) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-21) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-21) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-21) a CDR comprising the amino acid sequence of SEQ ID NO:
55
Group 22
(a-22) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-22) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-22) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-22) a CDR comprising the amino acid sequence of SEQ ID NO:
110,
(e-22) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-22) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 23
(a-23) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-23) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-23) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-23) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-23) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-23) a CDR comprising the amino acid sequence of SEQ ID NO:
115
Group 24
(a-24) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-24) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-24) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-24) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-24) a CDR comprising the amino acid sequence of SEQ ID NO:
120, and
(f-24) a CDR comprising the amino acid sequence of SEQ ID NO:
6.

309 more elements

A combination of an isolated polynucleotide comprising a nucleotide sequence that encodes a heavy chain of an isolated anti-human CD81 antibody, and an isolated polynucleotide comprising a nucleotide sequence that encodes the corresponding light chain of the anti-human CD81 antibody, wherein the anti-human CD81 antibody comprises all 6 complementarity determining regions (CDRs) described in any one of the following groups 1 to 24:

Group 1
(a-1) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-1) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-1) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-1) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-1) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-1) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 2
(a-2) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-2) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-2) a CDR comprising the amino acid sequence of SEQ ID NO:
37,
(d-2) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-2) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-2) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 3
(a-3) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-3) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-3) a CDR comprising the amino acid sequence of SEQ ID NO:
40,
(d-3) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-3) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-3) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 4
(a-4) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-4) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-4) a CDR comprising the amino acid sequence of SEQ ID NO:
43,
(d-4) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-4) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-4) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 5
(a-5) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-5) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-5) a CDR comprising the amino acid sequence of SEQ ID NO:
46,
(d-5) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-5) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-5) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 6
(a-6) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-6) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-6) a CDR comprising the amino acid sequence of SEQ ID NO:
49,
(d-6) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-6) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-6) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 7
(a-7) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-7) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-7) a CDR comprising the amino acid sequence of SEQ ID NO:
52,
(d-7) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-7) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-7) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 8
(a-8) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-8) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-8) a CDR comprising the amino acid sequence of SEQ ID NO:
43,
(d-8) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-8) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-8) a CDR comprising the amino acid sequence of SEQ ID NO:
55
Group 9
(a-9) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-9) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-9) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-9) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-9) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-9) a CDR comprising the amino acid sequence of SEQ ID NO:
61
Group 10
(a-10) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-10) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-10) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-10) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-10) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-10) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 11
(a-11) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-11) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-11) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-11) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-11) a CDR comprising the amino acid sequence of SEQ ID NO:
69, and
(f-11) a CDR comprising the amino acid sequence of SEQ ID NO:
70
Group 12
(a-12) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-12) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-12) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-12) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-12) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-12) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 13
(a-13) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-13) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-13) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-13) a CDR comprising the amino acid sequence of SEQ ID NO:
77,
(e-13) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-13) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 14
(a-14) a CDR comprising the amino acid sequence of SEQ ID NO:
80,
(b-14) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-14) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-14) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-14) a CDR comprising the amino acid sequence of SEQ ID NO:
81, and
(f-14) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 15
(a-15) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-15) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-15) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-15) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-15) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-15) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 16
(a-16) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-16) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-16) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-16) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-16) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-16) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 17
(a-17) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-17) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-17) a CDR comprising the amino acid sequence of SEQ ID NO:
52,
(d-17) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-17) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-17) a CDR comprising the amino acid sequence of SEQ ID NO:
93
Group 18
(a-18) a CDR comprising the amino acid sequence of SEQ ID NO:
98,
(b-18) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-18) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-18) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-18) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-18) a CDR comprising the amino acid sequence of SEQ ID NO:
99
Group 19
(a-19) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-19) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-19) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-19) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-19) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-19) a CDR comprising the amino acid sequence of SEQ ID NO:
99
Group 20
(a-20) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-20) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-20) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-20) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-20) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-20) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 21
(a-21) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-21) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-21) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-21) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-21) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-21) a CDR comprising the amino acid sequence of SEQ ID NO:
55
Group 22
(a-22) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-22) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-22) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-22) a CDR comprising the amino acid sequence of SEQ ID NO:
110,
(e-22) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-22) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 23
(a-23) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-23) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-23) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-23) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-23) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-23) a CDR comprising the amino acid sequence of SEQ ID NO:
115
Group 24
(a-24) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-24) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-24) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-24) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-24) a CDR comprising the amino acid sequence of SEQ ID NO:
120, and
(f-24) a CDR comprising the amino acid sequence of SEQ ID NO:
6.

309 more elements

A recombinant cell transformed with an expression vector comprising a polynucleotide comprising a nucleotide sequence that encodes the heavy chain of an isolated anti-human CD81 antibody, and with an expression vector comprising a polynucleotide comprising a nucleotide sequence that encodes the corresponding light chain of the anti-human CD81 antibody, wherein the anti-human CD81 antibody comprises all 6 complementarity determining regions (CDRs) described in any one of the following groups 1 to 24:

Group 1
(a-1) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-1) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-1) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-1) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-1) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-1) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 2
(a-2) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-2) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-2) a CDR comprising the amino acid sequence of SEQ ID NO:
37,
(d-2) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-2) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-2) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 3
(a-3) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-3) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-3) a CDR comprising the amino acid sequence of SEQ ID NO:
40,
(d-3) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-3) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-3) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 4
(a-4) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-4) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-4) a CDR comprising the amino acid sequence of SEQ ID NO:
43,
(d-4) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-4) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-4) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 5
(a-5) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-5) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-5) a CDR comprising the amino acid sequence of SEQ ID NO:
46,
(d-5) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-5) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-5) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 6
(a-6) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-6) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-6) a CDR comprising the amino acid sequence of SEQ ID NO:
49,
(d-6) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-6) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-6) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 7
(a-7) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-7) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-7) a CDR comprising the amino acid sequence of SEQ ID NO:
52,
(d-7) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-7) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-7) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 8
(a-8) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-8) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-8) a CDR comprising the amino acid sequence of SEQ ID NO:
43,
(d-8) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-8) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-8) a CDR comprising the amino acid sequence of SEQ ID NO:
55
Group 9
(a-9) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-9) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-9) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-9) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-9) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-9) a CDR comprising the amino acid sequence of SEQ ID NO:
61
Group 10
(a-10) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-10) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-10) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-10) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-10) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-10) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 11
(a-11) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-11) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-11) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-11) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-11) a CDR comprising the amino acid sequence of SEQ ID NO:
69, and
(f-11) a CDR comprising the amino acid sequence of SEQ ID NO:
70
Group 12
(a-12) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-12) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-12) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-12) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-12) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-12) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 13
(a-13) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-13) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-13) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-13) a CDR comprising the amino acid sequence of SEQ ID NO:
77,
(e-13) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-13) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 14
(a-14) a CDR comprising the amino acid sequence of SEQ ID NO:
80,
(b-14) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-14) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-14) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-14) a CDR comprising the amino acid sequence of SEQ ID NO:
81, and
(f-14) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 15
(a-15) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-15) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-15) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-15) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-15) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-15) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 16
(a-16) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-16) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-16) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-16) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-16) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-16) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 17
(a-17) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-17) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-17) a CDR comprising the amino acid sequence of SEQ ID NO:
52,
(d-17) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-17) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-17) a CDR comprising the amino acid sequence of SEQ ID NO:
93
Group 18
(a-18) a CDR comprising the amino acid sequence of SEQ ID NO:
98,
(b-18) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-18) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-18) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-18) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-18) a CDR comprising the amino acid sequence of SEQ ID NO:
99
Group 19
(a-19) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-19) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-19) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-19) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-19) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-19) a CDR comprising the amino acid sequence of SEQ ID NO:
99
Group 20
(a-20) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-20) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-20) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-20) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-20) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-20) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 21
(a-21) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-21) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-21) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-21) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-21) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-21) a CDR comprising the amino acid sequence of SEQ ID NO:
55
Group 22
(a-22) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-22) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-22) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-22) a CDR comprising the amino acid sequence of SEQ ID NO:
110,
(e-22) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-22) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 23
(a-23) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-23) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-23) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-23) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-23) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-23) a CDR comprising the amino acid sequence of SEQ ID NO:
115
Group 24
(a-24) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-24) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-24) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-24) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-24) a CDR comprising the amino acid sequence of SEQ ID NO:
120, and
(f-24) a CDR comprising the amino acid sequence of SEQ ID NO:
6.

309 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/836,907Filed 15 Mar 2013 · division

Priority

6 Dec 2010

Published

US 2013/0196378 A11 Aug 2013

Granted

27 Jan 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification21 codes

C07K 16/2896
Against receptors, cell surface antigens or cell surface determinants: against molecules with a "CD"-designation, not provided for elsewhere
A61K 39/395
Medicinal preparations containing antigens or antibodies: antibodies ; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 1/00
Drugs for disorders of the alimentary tract or the digestive system
A61P 17/06
Drugs for dermatological disorders: antipsoriatics

Family

Application61/420,136Us provisional application · filed 6 Dec 2010

Application13/311,124Parent of this division · filed 5 Dec 2011

US 2013/0196378 A1Pre-grant publication · published 1 Aug 2013

US 8,440,797 B2Parent of this division

US 2012/0141486 A1Published application

US 8,940,710 B2This patent

From the US filing history. Foreign family members aren’t listed.

Abstract

Claims12

Dependent claims

Group 1
(a-1) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-1) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-1) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-1) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-1) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-1) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 2
(a-2) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-2) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-2) a CDR comprising the amino acid sequence of SEQ ID NO:
37,
(d-2) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-2) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-2) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 3
(a-3) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-3) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-3) a CDR comprising the amino acid sequence of SEQ ID NO:
40,
(d-3) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-3) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-3) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 4
(a-4) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-4) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-4) a CDR comprising the amino acid sequence of SEQ ID NO:
43,
(d-4) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-4) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-4) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 5
(a-5) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-5) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-5) a CDR comprising the amino acid sequence of SEQ ID NO:
46,
(d-5) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-5) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-5) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 6
(a-6) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-6) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-6) a CDR comprising the amino acid sequence of SEQ ID NO:
49,
(d-6) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-6) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-6) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 7
(a-7) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-7) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-7) a CDR comprising the amino acid sequence of SEQ ID NO:
52,
(d-7) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-7) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-7) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 8
(a-8) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-8) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-8) a CDR comprising the amino acid sequence of SEQ ID NO:
43,
(d-8) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-8) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-8) a CDR comprising the amino acid sequence of SEQ ID NO:
55
Group 9
(a-9) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-9) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-9) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-9) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-9) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-9) a CDR comprising the amino acid sequence of SEQ ID NO:
61
Group 10
(a-10) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-10) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-10) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-10) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-10) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-10) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 11
(a-11) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-11) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-11) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-11) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-11) a CDR comprising the amino acid sequence of SEQ ID NO:
69, and
(f-11) a CDR comprising the amino acid sequence of SEQ ID NO:
70
Group 12
(a-12) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-12) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-12) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-12) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-12) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-12) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 13
(a-13) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-13) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-13) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-13) a CDR comprising the amino acid sequence of SEQ ID NO:
77,
(e-13) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-13) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 14
(a-14) a CDR comprising the amino acid sequence of SEQ ID NO:
80,
(b-14) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-14) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-14) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-14) a CDR comprising the amino acid sequence of SEQ ID NO:
81, and
(f-14) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 15
(a-15) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-15) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-15) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-15) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-15) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-15) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 16
(a-16) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-16) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-16) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-16) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-16) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-16) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 17
(a-17) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-17) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-17) a CDR comprising the amino acid sequence of SEQ ID NO:
52,
(d-17) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-17) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-17) a CDR comprising the amino acid sequence of SEQ ID NO:
93
Group 18
(a-18) a CDR comprising the amino acid sequence of SEQ ID NO:
98,
(b-18) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-18) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-18) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-18) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-18) a CDR comprising the amino acid sequence of SEQ ID NO:
99
Group 19
(a-19) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-19) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-19) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-19) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-19) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-19) a CDR comprising the amino acid sequence of SEQ ID NO:
99
Group 20
(a-20) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-20) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-20) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-20) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-20) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-20) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 21
(a-21) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-21) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-21) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-21) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-21) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-21) a CDR comprising the amino acid sequence of SEQ ID NO:
55
Group 22
(a-22) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-22) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-22) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-22) a CDR comprising the amino acid sequence of SEQ ID NO:
110,
(e-22) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-22) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 23
(a-23) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-23) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-23) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-23) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-23) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-23) a CDR comprising the amino acid sequence of SEQ ID NO:
115
Group 24
(a-24) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-24) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-24) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-24) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-24) a CDR comprising the amino acid sequence of SEQ ID NO:
120, and
(f-24) a CDR comprising the amino acid sequence of SEQ ID NO:
6.

309 more elements

Group 1
(a-1) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-1) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-1) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-1) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-1) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-1) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 2
(a-2) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-2) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-2) a CDR comprising the amino acid sequence of SEQ ID NO:
37,
(d-2) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-2) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-2) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 3
(a-3) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-3) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-3) a CDR comprising the amino acid sequence of SEQ ID NO:
40,
(d-3) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-3) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-3) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 4
(a-4) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-4) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-4) a CDR comprising the amino acid sequence of SEQ ID NO:
43,
(d-4) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-4) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-4) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 5
(a-5) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-5) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-5) a CDR comprising the amino acid sequence of SEQ ID NO:
46,
(d-5) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-5) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-5) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 6
(a-6) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-6) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-6) a CDR comprising the amino acid sequence of SEQ ID NO:
49,
(d-6) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-6) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-6) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 7
(a-7) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-7) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-7) a CDR comprising the amino acid sequence of SEQ ID NO:
52,
(d-7) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-7) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-7) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 8
(a-8) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-8) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-8) a CDR comprising the amino acid sequence of SEQ ID NO:
43,
(d-8) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-8) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-8) a CDR comprising the amino acid sequence of SEQ ID NO:
55
Group 9
(a-9) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-9) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-9) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-9) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-9) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-9) a CDR comprising the amino acid sequence of SEQ ID NO:
61
Group 10
(a-10) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-10) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-10) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-10) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-10) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-10) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 11
(a-11) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-11) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-11) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-11) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-11) a CDR comprising the amino acid sequence of SEQ ID NO:
69, and
(f-11) a CDR comprising the amino acid sequence of SEQ ID NO:
70
Group 12
(a-12) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-12) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-12) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-12) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-12) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-12) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 13
(a-13) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-13) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-13) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-13) a CDR comprising the amino acid sequence of SEQ ID NO:
77,
(e-13) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-13) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 14
(a-14) a CDR comprising the amino acid sequence of SEQ ID NO:
80,
(b-14) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-14) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-14) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-14) a CDR comprising the amino acid sequence of SEQ ID NO:
81, and
(f-14) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 15
(a-15) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-15) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-15) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-15) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-15) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-15) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 16
(a-16) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-16) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-16) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-16) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-16) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-16) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 17
(a-17) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-17) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-17) a CDR comprising the amino acid sequence of SEQ ID NO:
52,
(d-17) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-17) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-17) a CDR comprising the amino acid sequence of SEQ ID NO:
93
Group 18
(a-18) a CDR comprising the amino acid sequence of SEQ ID NO:
98,
(b-18) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-18) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-18) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-18) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-18) a CDR comprising the amino acid sequence of SEQ ID NO:
99
Group 19
(a-19) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-19) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-19) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-19) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-19) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-19) a CDR comprising the amino acid sequence of SEQ ID NO:
99
Group 20
(a-20) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-20) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-20) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-20) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-20) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-20) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 21
(a-21) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-21) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-21) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-21) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-21) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-21) a CDR comprising the amino acid sequence of SEQ ID NO:
55
Group 22
(a-22) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-22) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-22) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-22) a CDR comprising the amino acid sequence of SEQ ID NO:
110,
(e-22) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-22) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 23
(a-23) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-23) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-23) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-23) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-23) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-23) a CDR comprising the amino acid sequence of SEQ ID NO:
115
Group 24
(a-24) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-24) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-24) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-24) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-24) a CDR comprising the amino acid sequence of SEQ ID NO:
120, and
(f-24) a CDR comprising the amino acid sequence of SEQ ID NO:
6.

309 more elements

Group 1
(a-1) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-1) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-1) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-1) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-1) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-1) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 2
(a-2) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-2) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-2) a CDR comprising the amino acid sequence of SEQ ID NO:
37,
(d-2) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-2) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-2) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 3
(a-3) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-3) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-3) a CDR comprising the amino acid sequence of SEQ ID NO:
40,
(d-3) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-3) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-3) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 4
(a-4) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-4) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-4) a CDR comprising the amino acid sequence of SEQ ID NO:
43,
(d-4) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-4) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-4) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 5
(a-5) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-5) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-5) a CDR comprising the amino acid sequence of SEQ ID NO:
46,
(d-5) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-5) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-5) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 6
(a-6) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-6) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-6) a CDR comprising the amino acid sequence of SEQ ID NO:
49,
(d-6) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-6) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-6) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 7
(a-7) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-7) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-7) a CDR comprising the amino acid sequence of SEQ ID NO:
52,
(d-7) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-7) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-7) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 8
(a-8) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-8) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-8) a CDR comprising the amino acid sequence of SEQ ID NO:
43,
(d-8) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-8) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-8) a CDR comprising the amino acid sequence of SEQ ID NO:
55
Group 9
(a-9) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-9) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-9) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-9) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-9) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-9) a CDR comprising the amino acid sequence of SEQ ID NO:
61
Group 10
(a-10) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-10) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-10) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-10) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-10) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-10) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 11
(a-11) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-11) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-11) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-11) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-11) a CDR comprising the amino acid sequence of SEQ ID NO:
69, and
(f-11) a CDR comprising the amino acid sequence of SEQ ID NO:
70
Group 12
(a-12) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-12) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-12) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-12) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-12) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-12) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 13
(a-13) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-13) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-13) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-13) a CDR comprising the amino acid sequence of SEQ ID NO:
77,
(e-13) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-13) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 14
(a-14) a CDR comprising the amino acid sequence of SEQ ID NO:
80,
(b-14) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-14) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-14) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-14) a CDR comprising the amino acid sequence of SEQ ID NO:
81, and
(f-14) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 15
(a-15) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-15) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-15) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-15) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-15) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-15) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 16
(a-16) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-16) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-16) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-16) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-16) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-16) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 17
(a-17) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-17) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-17) a CDR comprising the amino acid sequence of SEQ ID NO:
52,
(d-17) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-17) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-17) a CDR comprising the amino acid sequence of SEQ ID NO:
93
Group 18
(a-18) a CDR comprising the amino acid sequence of SEQ ID NO:
98,
(b-18) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-18) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-18) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-18) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-18) a CDR comprising the amino acid sequence of SEQ ID NO:
99
Group 19
(a-19) a CDR comprising the amino acid sequence of SEQ ID NO:
60,
(b-19) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-19) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-19) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-19) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-19) a CDR comprising the amino acid sequence of SEQ ID NO:
99
Group 20
(a-20) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-20) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-20) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-20) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-20) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-20) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 21
(a-21) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-21) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-21) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-21) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-21) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-21) a CDR comprising the amino acid sequence of SEQ ID NO:
55
Group 22
(a-22) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-22) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-22) a CDR comprising the amino acid sequence of SEQ ID NO:
66,
(d-22) a CDR comprising the amino acid sequence of SEQ ID NO:
110,
(e-22) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-22) a CDR comprising the amino acid sequence of SEQ ID NO:
6
Group 23
(a-23) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-23) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-23) a CDR comprising the amino acid sequence of SEQ ID NO:
3,
(d-23) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-23) a CDR comprising the amino acid sequence of SEQ ID NO:
5, and
(f-23) a CDR comprising the amino acid sequence of SEQ ID NO:
115
Group 24
(a-24) a CDR comprising the amino acid sequence of SEQ ID NO:
1,
(b-24) a CDR comprising the amino acid sequence of SEQ ID NO:
2,
(c-24) a CDR comprising the amino acid sequence of SEQ ID NO:
90,
(d-24) a CDR comprising the amino acid sequence of SEQ ID NO:
4,
(e-24) a CDR comprising the amino acid sequence of SEQ ID NO:
120, and
(f-24) a CDR comprising the amino acid sequence of SEQ ID NO:
6.

309 more elements

Dependencies are inferred from the claim text.

Human monoclonal antibody

Life of this patent

Abstract

Claims12

Human monoclonal antibody

Life of this patent

Abstract

Claims12