Mutants PF4 polypeptides exhibiting an increased anti-angiogenic activity
AssigneesInstitut National De La Sante Et De La Recherche Medicale (Inserm), Universite De Bordeaux
InventorsAndreas Bikfalvi, Herve Prats, Cathy Quemener, Alexandre Dubrac
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Abstract
The present invention pertains to PF4 muteins which comprise a substitution at position 67, e.g. a L67H substitution, compared to the sequence of the wild-type PF4 protein. Such PF4 muteins exhibit an increased anti-angiogenie activity and a reduced affinity for proteoglycans compared to the wild-type PF4 protein.
Claims15
A polypeptide selected from the group consisting of SEQ ID Nos.:4, 5, 6, 7, or 8, or a fragment of at least 10 consecutive amino acids of said polypeptide, wherein said fragment includes positions 58 to 67 of SEQ ID NO:2.
Dependencies are inferred from the claim text.