E-selectin compositions and use thereof for inducing E-selectin tolerance
AssigneeThe United States of America as represented by the Secretary of the Department of Health and Human Services, National Institutes of Health
InventorsJohn M. Hallenbeck, Hideaki Wakita
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Abstract
The invention relates to compositions and methods for treating or preventing vascular dementia in a mammal comprising mucosal administration of an amount of E-selectin polypeptide sufficient to induce bystander immune tolerance in the mammal. Another aspect of the invention relates to compositions useful for treating or preventing vascular dementia.
Claims8
An isolated E-selectin polypeptide consisting of an amino-terminal signal sequence and the lectin, EGF, CR1 and CR2 domains, wherein the amino acid sequence of the signal sequence consists of SEQ ID NO:
- 27 or SEQ ID NO:
- 28.
Dependencies are inferred from the claim text.