Method for treating metabolic disorders including type 1 and type 2 diabetes mellitus
OwnerAvadhesha Surolia, Sarika Gupta +2inventors
InventorsAvadhesha Surolia, Sarika Gupta, Mahendra Pal Singh, Tandrika Chattopadhyay
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Abstract
A supramolecular insulin assembly and supramolecular exendin-4 assembly, which is useful as a protein therapeutic agent for the treatment of metabolic disorders particularly diabetes. The supramolecular assemblies disclosed in the present invention consists of insoluble and aggregated oligomers the protein. The invention also provides pharmaceutical compositions comprising the supramolecular assembly.
Claims12
A method for treating metabolic disorders selected from the group consisting of type 1 diabetes mellitus, type 2 diabetes mellitus and complications thereof, wherein said method comprising administering to a subject in need thereof a therapeutically effective amount of the pharmaceutical composition comprising an isolated and stable supramolecular insulin assembly (SIA), wherein said assembly comprises insoluble and aggregated oligomeric form of insulin and wherein said assembly is protease resistant, exhibits no binding to Congo Red, has both α-helical and β-sheet components, and releases biologically active insulin monomers in vitro or in vivo, which is effective for the alleviation of said disorder.
Dependencies are inferred from the claim text.