Cross-linked collagen comprising an antifungal agent
AssigneeMiMedx Group, Inc.
InventorThomas J. Koob
Life of this patent
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Abstract
The disclosure describes collagen constructs comprising antifungal agents, preferably, copper, and related methods.
Claims12
An antifungal cross-linked collagen construct comprising:
- a cross-linked collagen comprising collagen and one or more cross-linking agents and an antifungal amount of copper incorporated into the construct, wherein at least a portion of the copper is chelated to one or more of the cross-linking agents, and at least another portion of the copper is bound to the construct via one or more of covalent, non-covalent, ionic, and metallic bonds.
A method of manufacturing an antifungal cross-linked collagen construct comprising a cross-linked collagen comprising collagen and one or more cross-linking agents and an antifungal amount of copper incorporated into the construct, wherein at least a portion of the copper is chelated to one or more of the cross-linking agents, and at least another portion of the copper is bound to the construct via one or more of covalent, non-covalent, ionic, and metallic bonds, the method comprising contacting the cross-linked collagen construct with copper to provide the antifungal cross-linked collagen construct.
A method of treating a subject suffering from a fungal disease comprising administering an antifungal cross-linked collagen construct in a subject, wherein the construct comprises cross-linked collagen comprising collagen and one or more cross-linking agents and copper incorporated therein, wherein at least a portion of the copper is chelated to one or more of the cross-linking agents, and at least another portion of the copper is bound to the construct via one or more of covalent, non-covalent, ionic, and metallic bonds, to release an effective amount of copper into the subject.
Dependencies are inferred from the claim text.