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US 8,940,683 B2Granted
Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors
AssigneeRoy C. Levitt
InventorRoy C. Levitt
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AssigneeRoy C. Levitt
InventorRoy C. Levitt
Estimating the term…
The present invention is drawn to methods and compositions for treating inflammatory disorders of the lower airways, comprising administering an effective amount of an agent, which modulates the expression and/or activity of a proinflammatory cytokine or fragment thereof, preferably in a human. The proinflammatory cytokine contemplated by the invention includes IL-1, IL-6, IL-8 and TNF-alpha. The present invention describes a kit comprising a delivery device and a pharmaceutical composition for administration of the agent. The pharmaceutical composition includes at least one proinflammatory cytokine inhibitor, optionally one or more additional active ingredients, and at least one pharmaceutically active carrier. The delivery device further comprises a nebulizer, an inhaler, a powder dispenser, an intrapulmonary aerosolizer and a sub-miniature aerosolizer.
A method for treating an inflammatory disorder of lower airways in a human subject in need thereof by administering directly to the lower airways in the human subject, an effective amount of an agent consisting of anakinra and a pharmaceutical carrier, wherein the effective amount of the anakinra is 0.1 mg to 100 mg per day.
Dependencies are inferred from the claim text.