Sensor
AssigneeLighthouse Medical Limited
InventorsWilliam Paterson, Nick Barwell, Bruce Culbert, Barry Colin Crane
Life of this patent
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Abstract
A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed to the membrane; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.
Claims20
A process for producing a Reactive Oxygen Species (ROS)-quenching analyte-permeable membrane suitable for use in an optical sensor for detecting and/or quantifying the amount of analyte in a sample comprising:
- a. contacting a polypropylene hollow fibre membrane with a ROS-quenching precursor and a reducing agent;
- b. reducing the ROS-quenching precursor within pores of the polypropylene hollow fibre membrane to form a ROS-quenching agent within the pores of the polypropylene hollow fibre membrane;
- and
- optionally repeating steps (a) and (b).
A process for producing a Reactive Oxygen Species (ROS)-quenching analyte-permeable membrane on a sensor for detecting and/or quantifying the amount of analyte in a sample comprising:
- (a) contacting a polypropylene hollow fibre membrane with a ROS-quenching precursor and a reducing agent;
- (b) reducing the ROS-quenching precursor within pores of the polypropylene hollow fibre membrane to form a ROS-quenching agent within the pores of the membrane;
- and
- optionally repeating steps (a) and (b), and
- further comprising providing a sensor comprising a sensing region, wherein the sensor is suitable for detecting and/or quantifying the amount of analyte in a sample;
- forming the ROS-quenching analyte-permeable membrane into a barrier layer on at least a part of the sensing region and wherein the sensor is adapted so that analyte enters the sensing region of the sensor through said barrier layer.
A reactive oxygen species (ROS)-quenching, analyte-permeable membrane, suitable for use in an optical sensor for detecting and/or quantifying the amount of analyte in a sample, the membrane having an ROS-quenching activity sufficient to quench a solution of H2O2 having a concentration of 10 ppm, wherein said membrane is obtainable by a process comprising:
- (a) contacting a polypropylene hollow fibre membrane with a ROS-quenching precursor and a reducing agent;
- (b) reducing the ROS-quenching precursor within pores of the polypropylene hollow fibre membrane to form a ROS-quenching agent within the pores of the polypropylene hollow fibre membrane;
- and optionally repeating steps (a) and (b).
A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor comprising:
- a sensing region;
- and
- a barrier layer comprising a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed thereto;
- wherein the sensor is adapted so that the sample enters the sensing region of the sensor through said barrier layer,
- wherein the ROS-quenching, analyte-permeable membrane is obtainable by a process comprising:
- (a) contacting a polypropylene hollow fibre membrane with a ROS-quenching precursor and a reducing agent;
- (b) reducing the ROS-quenching precursor within pores of the polypropylene hollow fibre membrane to form a ROS-quenching agent within the pores of the polypropylene hollow fibre membrane;
- and
- optionally repeating steps (a) and (b).
Dependencies are inferred from the claim text.