Pipette tip, pipette system and method for performing analysis with the pipette tip and system

A pipette tip comprising a tip body, the tip body comprising:

• at least one inner surface and an outer surface;
• wherein the at least one inner surface defines the boundaries of an inner cavity;
• wherein the inner cavity has an upper end and a lower end;
• wherein the upper end has an upper opening;
• wherein the lower end has a lower opening;
• and
• wherein a portion of the at least one inner surface is coated with capturing agents of at least one type forming at least one capturing-agent region on the at least one inner surface;
• wherein the at least one capturing-agent region is capable of selectively binding target substances of at least one type comprised in a sample to form at least agent-target conjugates defining at least one agent target region;
• an EM waveguiding medium for receiving light emanating from the at least one agent target region;
• and
• an analysis system that comprises:
• a sensor for detecting light guided in the EM waveguiding medium;
• and
• a power source connected with the sensor for powering the sensor.

A pipette tip comprising a tip body, the tip body comprising:

• at least one inner surface and an outer surface;
• wherein the at least one inner surface defines the boundaries of an inner cavity;
• wherein the inner cavity has an upper end and a lower end;
• wherein the upper end has an upper opening;
• and
• wherein the lower end has a lower opening;
• an EM waveguiding medium for receiving light emanating from at least a portion of the at least one inner surface;
• and
• at least a portion of a side wall of the pipette tip having a lower index of refraction than the index of refraction of the inner cavity, such that the inner cavity serves as the EM waveguiding medium.

A pipette tip comprising a tip body, the tip body comprising:

• a lower portion and a middle portion;
• at least one inner surface and an outer surface;
• wherein the at least one inner surface defines the boundaries of an inner cavity;
• wherein the inner cavity has an upper end and a lower end;
• wherein the upper end has an upper opening;
• and
• wherein the lower end has a lower opening;
• and
• an EM waveguiding medium for receiving light emanating from at least a portion of the at least one inner surface;
• and
• wherein the lower portion of-the tip body is reversibly retractable into the inner cavity of the middle portion of the tip body.