Methods for modulating de novo hepatic lipogenesis by modulating XBP-1 activity
AssigneeCornell University
InventorsAnn-Hwee Lee, Laurie H. Glimcher
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Abstract
The invention provides methods and compositions for modulating the expression, processing, post-translational modification, stability and/or activity of XBP-1 protein, or a protein in a signal transduction pathway involving XBP-I to treat dyslipidemias and steatosis disorders. The present invention also pertains to methods for identifying compounds that modulate the expression, processing, post-translational modification, and/or activity of XBP-I protein or a molecule in a signal transduction pathway involving XBP-1.
Claims50
A method of treating hyperlipidemia comprising administering a nucleic acid molecule that downmodulates XBP-1 gene expression to a subject having hyperlipidemia in an amount sufficient to downmodulate de novo hepatic lipogenesis, to thereby treat hyperlipidemia in the subject.
A method of treating atherosclerosis comprising administering a nucleic acid molecule that downmodulates XBP-1 gene expression to a subject having atherosclerosis in an amount sufficient to downmodulate de novo hepatic lipogenesis, to thereby treat atherosclerosis in the subject.
A method of treating hepatic steatosis comprising administering a nucleic acid molecule that downmodulates XBP-1 gene expression to a subject having hepatic steatosis in an amount sufficient to downmodulate de novo hepatic lipogenesis, to thereby treat hepatic steatosis in the subject.
A method of treating steatohepatitis comprising administering a nucleic acid molecule that downmodulates XBP-1 gene expression to a subject having steatohepatitis in an amount sufficient to downmodulate de novo hepatic lipogenesis, to thereby treat steatohepatitis in the subject.
A method of treating non-alcoholic hepatic steatohepatitis comprising administering a nucleic acid molecule that downmodulates XBP-1 gene expression to a subject having non-alcoholic hepatic steatohepatitis in an amount sufficient to downmodulate de novo hepatic lipogenesis, to thereby treat non-alcoholic hepatic steatohepatitis in the subject.
Dependencies are inferred from the claim text.