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AssigneeRoquette Freres
InventorsBaptiste Boit, Philippe Lefevre, Jose Lis
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Disclosed is a powder composition of mannitol crystals, produced by: (i) the crystallization of mannitol in a solvent; followed by (ii) a step of separating the crystals from the resulting crystal suspension; (iii) a step of drying the crystals; and (iv) a selection step, the composition having a particle size distribution, as determined by laser particle sizing, of 72 to 99.9 vol % of particles having a particle size greater than 75 μm, of 0.1 to 60 vol % of particles larger than 250 μm, and a mean diameter of between 100 and 300 μm. Also described is a method for producing such a composition by a step of crystallizing a mannitol syrup followed by drying the mannitol crystals, a step of selecting particles, and a step of collecting a fraction of the powder composition including 72 to 99.9% of particles having a particle size greater than 75 μm.
A pulverulent composition formed of mannitol crystals being of a polyhedral structure which is obtained by (i) crystallization of mannitol from a solvent, followed by (ii) a step of separation of the crystals from the suspension of crystals which is obtained, (iii) a step of drying the crystals in manner other than granulation or spray-drying and (iv) a step of selection, wherein the crystals are not constituted by agglomerates or atomisates, wherein the particle size distribution by volume, determined by laser particle size analysis, exhibits:
A process for producing a pulverulent composition formed of mannitol crystals being of a polyhedral structure and comprising from 72 to 99.9% of particles with a particle size of greater than 75 said process comprising:
Dependencies are inferred from the claim text.