Microemulsions and its use for preventing airway diseases
AssigneeNares AB
InventorsPer Wollmer, Morgan Andersson, Lennart Greiff, Thomas Landh
Life of this patent
Estimating the term…
Abstract
The invention relates to novel microemulsions comprising a non-polar lipid, at least one polar solvent, a surfactant, and a polar lipid. A microemulsion of these ingredients provides an environment that substantially encloses airborne particles, and it can be used for entrapping such particles. The inventive microemulsions are especially adapted for the prevention of symptoms in mammals, which are indirectly or directly caused by airborne particles. The invention further provides compositions comprising such microemulsions and methods of treatment comprising administering the same.
Claims10
A composition suitable for administration to peripheral membrane linings of the nose, the eyes, the ears, the pharynx and/or the larynx of a mammal characterized in that said composition comprises a pharmaceutically effective amount of a microemulsion comprising 5 to 35 wt % of a non-polar animal or vegetable oil, 10 to 55 wt % of at least one polar solvent selected from the group consisting of water, a buffer, an alcohol, and mixtures thereof, and at least one surfactant selected from a polysorbate, a poloxamer and a fatty acid polyoxyethylene, wherein the microemulsion further comprises 20-50 wt % of a monoacyl glycerol;
- wherein said composition also comprises a pharmaceutical active agent.
A method of entrapping airborne particles in order to reduce their tendency to directly or indirectly cause respiratory tract conditions in a subject, said method comprising contacting at least one surface (preferably at least one mucosal surface) of said subject with a composition comprising 5 to 35 wt % of a non-polar animal or vegetable oil, 10 to 55 wt % of at least one polar solvent selected from the group consisting of water, a buffer, an alcohol, and mixtures thereof, and at least one surfactant selected from a polysorbate, a poloxamer and a fatty acid polyoxyethylene, wherein the microemulsion further comprises 20-50 wt % of a monoacyl glycerol;
- wherein said composition optionally also comprises a pharmaceutical active agent.
A method of retarding or inhibiting the interaction of airborne particles with the mucosal membranes of a mammal, said method comprising the step of administering to said exterior mucosal membranes of said mammal a prophylactically effective amount of a composition suitable for administration to peripheral membrane linings of the nose, the eyes, the ears, the pharynx, and/or the larynx of a mammal, characterized in that said composition comprises a pharmaceutically effective amount of a microemulsion comprising 5 to 35 wt % of a non-polar animal or vegetable oil, 10 to 55 wt % of at least one polar solvent selected from the group consisting of water, a buffer, an alcohol, and mixtures thereof, and at least one surfactant selected from a polysorbate, a poloxamer and a fatty acid polyoxyethylene, wherein the microemulsion further comprises 20-50 wt % of a monoacyl glycerol;
- wherein said composition optionally also comprises a pharmaceutical active agent.
A method of entrapping airborne particles in order to reduce their tendency to directly or indirectly cause respiratory tract conditions in a subject, including airway diseases caused by airbourne pollen, bacteria and/or viruses, said method comprising contacting at least one surface of said subject with a composition comprising 5 to 35 wt % of a non-polar animal or vegetable oil, 10 to 55 wt % of at least one polar solvent selected from the group consisting of water, a buffer, an alcohol, and mixtures thereof, and at least one surfactant selected from a polysorbate, a poloxamer and a fatty acid polyoxyethylene, wherein the microemulsion further comprises 20-50 wt % of a monoacyl glycerol.
Dependencies are inferred from the claim text.