Process for making dry and stable hemostatic compositions
AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorAndreas Goessl
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Abstract
Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a dry granular preparation of a biocompatible polymer suitable for use in hemostasis, b) coating the granules in said dry granular preparation with a preparation of a coagulation inducing agent, thereby obtaining coagulation inducing agent coated polymer granules, c) filling said coagulation inducing agent coated polymer granules into a final container, d) finishing the final container to a storable pharmaceutical device containing said coagulation inducing agent coated polymer granules as a dry and stable hemostatic composition.
Claims19
A process for making a dry and stable hemostatic composition, said process comprising:
- a) providing a dry granular preparation of a biocompatible polymer suitable for use in hemostasis, wherein the biocompatible polymer suitable for use in hemostasis contains a cross-linked gelatin;
- b) coating the granules in said dry granular preparation with a preparation of a coagulation inducing agent, thereby obtaining coagulation inducing agent coated polymer granules, wherein:
- said coagulation inducing agent preparation is a thrombin solution, and
- only an outer layer of the granules swells and soaks up at least some of the thrombin solution upon coating the granules with the preparation of the coagulation inducing agent;
- c) filling said coagulation inducing agent coated polymer granules into a final container;
- and
- d) finishing the final container to a storable pharmaceutical device containing said coagulation inducing agent coated polymer granules as a dry and stable hemostatic composition, wherein the hemostatic composition has a moisture content below 5%.
Dependencies are inferred from the claim text.