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US 8,940,333 B2Granted
Amphiphilic block copolymers and nanoparticles comprising the same
AssigneeIndustrial Technology Research Institute
InventorsMing-Fa Hsieh, Hsuen-Tseng Cha'ng, Chin-Fu Chen, Yuan-Chia Chang, Pei Kan, Tsai-Yu Lin
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Abstract
An amphiphilic block copolymer is disclosed. The amphiphilic block copolymer includes one or more hydrophilic polymers, one or more hydrophobic polymer, and one or more zwitterions. The invention also provides a nanoparticle and carrier including the amphiphilic block copolymer for delivery of water insoluble drugs, growth factors, genes, or water insoluble cosmetic substances.
Claims5
A nanocarrier, comprising:
- a nanoparticle comprising one or more block copolymers, wherein the block copolymer comprises a hydrophobic block, a hydrophilic block bonded to the hydrophobic block, and one zwitterion, wherein the zwitterion is only bonded to the hydrophobic block, and the zwitterion has one positive charge and one negative charge, wherein the nanoparticle has a hydrophobic interior and hydrophilic surface, wherein the hydrophobic block comprises polycaprolactone (PCL), polyvalerolactone (PVL), poly(lactide-co-glycolide) (PLGA), polylactic acid (PLA), polybutyrolactone (PBL), polyglycolide, or polypropiolactone (PPL), and the hydrophilic block comprises polyethylene glycol (PEG), hyaluronic acid (HA), or poly-γ-glutamic acid (PGA);
- and
- an active substance encapsulated in the particle, wherein the nanoparticle has a diameter of about 20-1,000 nm.
Dependencies are inferred from the claim text.