Transdermal patch and method for delivery of vitamin B12
AssigneeVita Sciences LLC
InventorJon D. Zeltman
Life of this patent
Estimating the term…
Abstract
The present invention is directed to compositions and devices for transdermally administering vitamin B12 to a subject. In one aspect, a vitamin B12 containing composition suitable for transdermal administration is provided in the form of a shelf stable transdermal delivery patch. Such patches contain vitamin B12 combined with selected penetration enhancers and vitamin B12 stabilizers.
Claims4
A shelf stable composition useful for the transdermal delivery of vitamin B12 to a subject, consisting of:
- (a) vitamin B12 at 0.1 wt % to 15.0 wt %;
- (b) sodium selenite at 0.01 wt % to 1.0 wt %;
- (c) menthone at 0.8 wt % to 12.0 wt %;
- (d) propylene glycol at 0.5 wt % to 12.0 wt %;
- (e) nonionic surfactant at 0.1% to 1.0 wt %
- (f) polyurethane polymer associative thickener at 0.6 wt % to 6.0 wt %;
- (g) added water at 0.3 wt % to 50 wt %;
- and
- (h) acrylic co-polymer at 40.0 wt % to 97.6 wt %.
A method of manufacturing a shelf stable transdermal delivery patch for transdermally delivering vitamin B12 to a subject, said method comprising:
- (a) roller-coating a composition consisting of:
- (i) vitamin B12 at 0.1 wt % to 15.0 wt %;
- (ii) sodium selenite at 0.01 wt % to 1.0 wt %;
- (iii) menthone at 0.8 wt % to 12.0 wt %;
- (iv) propylene glycol at 0.5 wt % to 12.0 wt %;
- (v) nonionic surfactant at 0.1% to 1.0 wt %
- (vi) polyurethane polymer associative thickener at 0.6 wt % to 6.0 wt %;
- (vii) added water at 0.3 wt % to 50 wt %;
- and
- (viii) acrylic co-polymer at 40.0 wt % to 97.6 wt %;
- onto an impermeable release layer to form a skin contact adhesive layer adjacent to said release layer;
- (b) evaporating the water from said composition by heating the composition to a temperature no greater than 215 degrees F.;
- (c) laminating a backing layer to said skin contact adhesive layer;
- and
- (d) cutting a multilayered product formed in steps (a)-(c) into a pre-selected shape and size thereby providing a shelf stable transdermal delivery patch.
Dependencies are inferred from the claim text.