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US 8,940,307 B2Granted
Lectin compositions and methods for modulating an immune response to an antigen
AssigneeOpSaniTx LLC
InventorsAndrew H. Segal, Elihu Young
Life of this patent
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Abstract
The present invention also relates to a method of reducing metastases in a subject comprising administering to the subject a composition comprising a multifunctional molecule comprising a first part which is capable of binding to an antigen bearing target and a second part which is capable of binding to a cell.
Claims16
A composition suitable for administration to a subject, said composition comprising an antigen bearing target and a plurality of fusion polypeptides, each of said fusion polypeptides including:
- a first amino acid sequence which can bind to a carbohydrate and is HA, and
- a second amino acid sequence comprising a ligand for a cell surface polypeptide of a leukocyte, said ligand being GM-CSF;
- wherein said plurality of fusion polypeptides of said composition comprise fusion polypeptides which are bound to a carbohydrate on said antigen bearing target;
- and
- wherein said plurality of fusion polypeptides of said composition further comprise fusion polypeptides which are not bound to a carbohydrate on said antigen bearing target,
- wherein said antigen bearing target is chosen from the group consisting of:
- a tumor cell a bacterial cell a fungal cell, a cell of a parasite, a mammalian cell, and an insect cell.
4 more elements
Dependencies are inferred from the claim text.