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AssigneeFundaco Oswaldo Cruz
InventorsJose Procopio Moreno Senna, Joao Luiz Sampaio Queiroz, Nadia Maria Batoreu, Maria da Gloria Martins Teixeira
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The present invention relates to monoclonal antibodies capable of recognizing and binding to the PBP2-a protein and to other proteins having sequences homologous to PBP2-a, including pathogenic species such as the methyciline-resistant Staphylococcus Aureus (MRSA), coagulase-negative Staphilococcus, Staphylococcus sciuri and Enterococcus, and any other bacteria containing the PBP2-a protein or homologous sequences. The invention also relates to the use of the monoclonal antibodies capable of recognizing and binding to the PBP2-a protein and to other proteins having sequences homologous to PBP2-a in a complementary immunodiagnostic test for detecting resistance to beta-lactam antibiotics.
An isolated monoclonal antibody capable of binding to PBP2a protein from methicillin-resistant bacteria, said antibody comprising a variable heavy chain possessing a CDR1 region that includes SEQ ID NO:12, a CDR2 region that includes SEQ ID NO:13, a CDR3 region that includes SEQ ID NO:14 and a variable light chain possessing a CDR1 region that includes SEQ ID NO:6, a CDR2 region that includes SEQ ID NO:7 and a CDR3 region that includes SEQ ID NO:8.
An isolated monoclonal antibody capable of binding to PBPS protein from Enterococcus spp., said antibody comprising a variable heavy chain possessing a CDR1 region that includes SEQ ID NO:12, a CDR2 region that includes SEQ ID NO:13, a CDR3 region that includes SEQ ID NO:14 and a variable light chain possessing a CDR1 region that includes SEQ ID NO:6, a CDR2 region that includes SEQ ID NO:7 and a CDR3 region that includes SEQ ID NO:8.
An isolated monoclonal antibody capable of binding to PBP2a protein from methicillin-resistant bacteria and/or PBP5 protein from Enterococcus spp, said antibody comprising a variable heavy chain possessing a CDR1 region that includes the amino acid sequence encoded by SEQ ID NO:15, a CDR2 region that includes the amino acid sequence encoded by SEQ ID NO:16, a CDR3 region that includes the amino acid sequence encoded by SEQ ID NO:17 and a variable light chain possessing a CDR1 region that includes the amino acid sequence encoded by SEQ ID NO:9, a CDR2 region that includes the amino acid sequence encoded by SEQ ID NO:10, and a CDR3 region that includes the amino acid sequence encoded by SEQ ID NO:11.
Dependencies are inferred from the claim text.