Compositions and methods for enhancing virus efficacy

A method of enhancing the production of a virus in cells comprising:

• producing a composition comprising the virus and a viral sensitizing agent by administering the viral sensitizing agent to said cells prior to, after, or concurrently with the virus;
• and
• culturing the virus and cells to enhance the production of the virus in said cells;
• wherein the viral sensitizing agent is of the formula:
• or an N-oxide, pharmaceutically acceptable addition salt, quaternary amine, or stereochemically isomeric form thereof, wherein:
• A is a 5-membered heterocyclic ring comprising 1-4 heteroatoms selected from O, N, and S and 1 or 2 double bonds;
• R1 is H, oxo, alkoxycarbonyl, hydrazinylcarbonylalkyl, or amino;
• R2 is nothing, alkyl, halogen, carboxyl, heteroarylcarbonylamino, or hydroxyl;
• R3 is nothing, H, alkyl, halogen, or heterocyclylaminosulfonyl;
• and
• R4 is H, alkyl, unsubstituted aryl, or aryl substituted with 1-3 halogens.