Simian adenoviruses SAdV-43, -45, -46, -47, -48, -49, and -50 and uses thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsSoumitra Roy, James M. Wilson, Luc H. Vandenberghe
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Abstract
A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
Claims14
An adenovirus having a capsid comprising a hexon protein, a penton protein, and fiber protein, said hexon protein being a hexon protein of SAdV-46 comprising amino acids 1 to 959 of SEQ ID NO:
- 79;
- said capsid encapsidating a heterologous molecule comprising a gene operably linked to expression control sequences which direct transcription, translation, and/or expression thereof in a host cell.
A recombinant adenovirus having a capsid comprising a fiber protein, a penton protein and a hexon protein, said hexon comprising (a) the full-length of amino acids 51 to 959 of SEQ ID NO:
- 79 from SAdV-46 or (b) the full-length of amino acids 1 to 909 of SEQ ID NO:
- 79 from SAdV-46 said adenovirus capsid encapsidating a heterologous molecule carrying comprising a gene operably linked to expression control sequences which direct transcription, translation, and/or expression thereof in a host cell.
Dependencies are inferred from the claim text.