Fusion molecules and IL-15 variants
AssigneeAltor BioScience Corporation
InventorsHing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-ping Han
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Abstract
The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
Claims8
A method of stimulating immune responses in a mammal comprising administering to the mammal an effective amount of an isolated human interleukin 15 (hIL-15) variant comprising an amino acid substitution at position 72 of a mature hIL-15 sequence, wherein the amino acid substitution results in an hIL-15 variant that has IL-15 agonist activity and increased binding activity for the IL-15 receptor beta/gamma chain (IL-15RβγC) receptors compared to the native hIL-15 polypeptide.
Dependencies are inferred from the claim text.