Back to results
US 8,940,275 B2Granted
Nanoparticles based on gadolinium coordination polymers as highly sensitive T1 MRI contrast agents
AssigneesKent State University, Case Western Reserve University
InventorsSongping D. Huang, Yongxiu Li, James P. Basilion, Jihua Hao, Christopher Flask
Life of this patent
Estimating the term…
Abstract
An agent for imaging of a biological system or delivering drugs to a biological system including one or more nanoparticles formed of at least one gadolinium coordination polymer.
Claims22
A contrast agent comprising:
- one or more gadolinium nanoparticles derived from a compound having the formula AGd[FeII(CN)6].nH2O where A is Li+, Na+, K+, Rb+, CS+, NH4+, or Tl+ and wherein n is from 1 to about 10, or Gd[MIII(CN)6].nH2O where M is Cr, Mn, Fe, Co or Ru, and where n is from 1 to about 10, or both;
- and
- said one or more gadolinium nanoparticles having a coating thereon comprising a hydrophilic biocompatible polymer and a carboxylic acid, said coated gadolinium nanoparticles being soluble in water.
A method for the preparation of a contrast agent comprising gadolinium nanoparticles, said process comprising the step of:
- reacting an aqueous solution of GdCl3 with K4[Fe(CN)6] in the presence of a hydrophilic biocompatible polymer.
A contrast agent composition, comprising:
- a plurality of nanoparticles derived from a compound having the formula AGd[FeII(CN)6].nH2O, where A is Li+, Na+, K+, Rb+, Cs+, NH4+, or TI+;
- and wherein n is from about 1 to about 10, or having the formula Gd[MIII(CN)6].nH2O wherein M is Cr, Mn, Fe, Co, or Ru, wherein n is from 1 to about 10, or both;
- said nanoparticles containing a hydrophilic biocompatible polymer coating and being soluble in water.
Dependencies are inferred from the claim text.