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US 8,940,274 B2Granted
Radioiodination method
AssigneeGe Healthcare Limited
InventorsMichelle Avory, Harry John Wadsworth, Robert James Domett Nairne
Life of this patent
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Abstract
The present invention provides a novel method of labelling biological targeting molecules (BTMs) of interest with radioiodine. Also provided are functionalised BTMs useful in the method, as well as methods of preparing such functionalised BTMs under mild conditions.
Claims11
A method of radioiodination of a biological targeting moiety, said method comprising:
- (i) provision of a functionalised BTM of Formula (Ia) or (Ib):
- (ii) reaction of the functionalised BTM of either Formula (Ia) or (Ib) with radioactive iodide ion in the presence of an oxidising agent, to give the desired radioiodinated product as a conjugate of Formula (IIa) or (IIb) respectively;
- wherein:
- BTM is the biological targeting moiety;
- L1 is a linker group which may be present or absent;
- Q is Ra3Sn— or KF3B—, where each Ra is independently C1-4 alkyl;
- I* is a radioisotope of iodine.
4 more elements
Dependencies are inferred from the claim text.