Human anti-tau antibodies
AssigneesUniversity of Zurich, Biogen Idec International Neuroscience GmbH
InventorsRoger Nitsch, Feng Chen, Jan Grimm, Jean-Luc Baeriswyl, Christoph Hock
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Abstract
Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for tau are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for tau targeted immunotherapy and diagnosis, respectively.
Claims9
A human monoclonal anti-tau antibody or tau binding fragment thereof comprising a heavy chain variable region (VH) and a light chain variable region (VL) wherein:
- (a) the VH comprises a heavy chain CDR1, CDR2, and CDR3 comprising the amino acid sequences of SEQ ID NO:
- 23, 24, and 25, respectively;
- and
- (b) the VL comprises a light chain CDR1, CDR2, and CDR3 comprising the amino acid sequences of SEQ ID NO:
- 26, 27, and 28, respectively;
- wherein the VH does not comprise an asparagine at Kabat numbering position 30.
A human monoclonal anti-tau antibody or tau binding fragment thereof comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein
- (a) the VH comprises a heavy chain CDR1, CDR2, and CDR3 comprising the amino acid sequences of SEQ ID NO:
- 23, 24, and 25, respectively;
- (b) the VL comprises a light chain CDR1, CDR2, and CDR3 comprising the amino acid sequences of SEQ ID NO:
- 26, 27, and 28, respectively;
- and
- (c) the antibody is a non-naturally occurring variant of a monoclonal antibody comprising the VH of SEQ ID NO:9 and VL of SEQ ID NO:11.
A human monoclonal anti-tau antibody or tau binding fragment thereof comprising
- (a) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 93, and
- (b) a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 11.
Dependencies are inferred from the claim text.