Modulating the alternative complement pathway
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsJoshua M. Thurman, V. Michael Holers
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Abstract
Provided herein are compositions, including pharmaceutical compositions, and methods for modulating, i.e., stimulating or inhibiting, activity of the alternative complement pathway, and methods of identifying factor H-binding proteins.
Claims6
A method of treating a pathogen infection in an individual in need thereof, comprising administering to the individual a composition in an amount effective to stimulate the alternative complement pathway activity in said individual, said composition comprising annexin A2 or a biologically-active fragment thereof, wherein said pathogen is a cell susceptible to osmolytic pore formation by the membrane attack complex of the alternative complement pathway, thereby treating said pathogen infection.
Dependencies are inferred from the claim text.