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AssigneeGL Sciences Incorporated
InventorsShota Miyazaki, Hiroyuki Terashima, Masahiko Nyudo, Masayoshi Ohira, Kei Morisato, Masahiro Furuno
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To use a monolithic silica body in chromatography with a HPLC column or a GC column and to simplify the use thereof as a separation medium, it is intended to provide a method of cladding a main body of a monolithic adsorbent or separating agent with glass so as to protect the outer surface, and to provide a separation medium prepared by the method. To this end, a monolithic silica body alone is formed by molding, and the molding is coated with a glass body; and then the glass body and the monolithic silica body are fused and integrated at the melting temperature of the glass body at an appropriate pressure. The surface of the resulting monolithic silica body clad with glass is strongly protected by the glass, and the homogeneity of the interior of the monolithic silica body is maintained, and thus uniform flow of a sample solution ensures analytical accuracy.
A method of cladding a monolithic silica body, the method comprising providing a rod-shaped monolithic silica body having SiO2 as a main component, coating the monolithic silica body with a glass body having the same main component as the monolithic silica body, and fusing the monolithic silica body and the glass body at the melting temperature of the glass body at a predetermined pressure to provide an integrated monolith silica body and glass body, and chemically bonding SiO2 of the monolithic silica body and SiO2 of the glass body with each other, thereby assimilating the monolithic silica body and the glass body with each other.
A separation medium prepared by coating a side surface of a rod-shaped monolithic silica body with a glass body, wherein the monolithic silica body and the glass body both have SiO2 as a main component and fusing the monolithic silica body and the glass body to integrate the two, and chemically bonding SiO2 of the monolithic silica body and SiO2 of the glass body with each other, thereby assimilating the monolithic silica body and the glass body with each other.
A separation medium, wherein a side surface of a monolithic silica body molded into a rod shape is coated with a glass body having SiO2 as the same main component as the monolithic silica body and the monolithic silica body and the glass body are fused and integrated, and SiO2 of the monolithic silica body and SiO2 of the glass body are chemically bonded with each other, and the monolithic silica body and the glass body are assimilated with each other.
Dependencies are inferred from the claim text.