Vault and vault-like carrier molecules

An assembled vault-like particle comprising multiple copies of a modified naturally occurring sequence of MVP, where the naturally occurring sequence of MVP is modified by adding an amino acid sequence to the N-terminal of the MVP that creates a sensor in the assembled vault-like particle.

An assembled vault-like particle comprising multiple copies of a modified naturally occurring sequence of MVP, where the naturally occurring sequence of MVP is modified by adding an amino acid sequence to the C-terminal of the naturally occurring sequence of MVP which results in one or more than one receptor-binding domain.

An assembled vault-like particle comprising multiple copies of a modified naturally occurring sequence of MVP, where the naturally occurring sequence of MVP is modified by adding both an amino acid sequence to the C-terminal of the naturally occurring sequence of MVP and an amino acid sequence to the N-terminal of the naturally occurring sequence of MVP.

An assembled vault-like particle comprising multiple copies of a naturally occurring sequence of MVP or a modified naturally occurring sequence of MVP, and further comprising a modified naturally occurring sequence of VPARP or a modified portion of the naturally occurring sequence of VPARP comprising at least about 150 consecutive residues from residue 1473 to residue 1724 of VPARP SEQ ID NO:

• 3 or an intraspecies variation in the sequence thereof in the assembled vault-like particle, wherein the naturally occurring sequence of VPARP or the portion of naturally occurring sequence of VPARP is modified by adding an amino acid sequence to the C-terminal, adding an amino acid sequence to the N-terminal, or adding an amino acid sequence to the C-terminal and adding an amino acid sequence to the N-terminal of the naturally occurring sequence of VPARP or the portion of naturally occurring sequence of VPARP.

An assembled vault-like particle comprising multiple copies of a naturally occurring sequence of MVP or a modified naturally occurring sequence of MVP, and further comprising a modified naturally occurring sequence of VPARP or a modified portion of the naturally occurring sequence of VPARP comprising residues from about residue 1562 to 1724 of SEQ ID NO:3 or an intraspecies variation in the sequence thereof in the assembled vault-like particle, wherein the naturally occurring sequence of VPARP or the portion of the naturally occurring sequence of VPARP is modified by adding an amino acid sequence to the C-terminal, adding an amino acid sequence to the N-terminal, or adding an amino acid sequence to the C-terminal and adding an amino acid sequence to the N-terminal of the naturally occurring sequence of VPARP or the portion of the naturally occurring sequence of VPARP.

An assembled vault-like particle comprising multiple copies of a naturally occurring sequence of MVP or a modified naturally occurring sequence of MVP, and further comprising a modified naturally occurring sequence of VPARP or a modified portion of the naturally occurring sequence of VPARP comprising residues from about residue 1473 to 1724 of SEQ ID NO:3 or an intraspecies variation in the sequence thereof in the assembled vault-like particle, wherein the naturally occurring sequence of VPARP or the portion of the naturally occurring sequence of VPARP is modified by adding an amino acid sequence to the C-terminal, adding an amino acid sequence to the N-terminal, or adding an amino acid sequence to the C-terminal and adding an amino acid sequence to the N-terminal of the naturally occurring sequence of VPARP or the portion of the naturally occurring sequence of VPARP.