Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer
AssigneeNuCana BioMed Limited
InventorsChristopher McGuigan, Jan Balzarini, Magdalena Slusarczyk, Blanka Gonczy, Paola Murziani
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Abstract
Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase.
Claims32
A compound which is 5-fluoro-2′-deoxyuridine-5′-O-[1-naphthyl(benzoxy-L-alaninyl)]phosphate (CPF373), or a pharmaceutically acceptable salt or metabolite thereof.
A compound which is 5-fluoro-2′-deoxyuridine-5′-O-[1-naphthyl(benzoxy-L-alaninyl)]phosphate (CPF373), or a pharmaceutically acceptable salt thereof.
A compound which is 5-fluoro-2′-deoxyuridine-5′-O-[1-naphthyl(benzoxy-L-alaninyl)]phosphate (CPF373), or a metabolite thereof.
A compound which is 5-fluoro-2′-deoxyuridine-5′-O-[1-naphthyl(benzoxy-L-alaninyl)]phosphate (CPF373).
Dependencies are inferred from the claim text.