System for treating and preventing breast cancer
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsDennis L. Panicali, Gail P. Mazzara, Linda R. Gritz, Jeffrey Schlom, Kwong-Yok Tsang, James W. Hodge
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Abstract
The present invention is directed to a system for treating individuals at risk of or suffering from breast cancer. The system comprises administering to the individual a recombinant poxvirus, where the poxvirus contains in a foreign nucleic acid encoding at least one breast cancer antigen.
Claims27
A method for inducing an immunological response against a cell expressing a breast cancer associated antigen, wherein the breast cancer associated antigen is mucin and/or carcinoembryonic antigen, in a human, wherein the method comprises:
- (a) selecting a human having breast cancer,
- (b) administering to the individual a first poxvirus vector comprising SEQ ID NO:1 and SEQ ID NO:3,
- (c) at regular intervals thereafter administering at least a second poxvirus vector comprising SEQ ID NO:1 and SEQ ID NO:3,
- such that an immunological response against the cell expressing the breast cancer associated antigen is induced in the individual.
A method for inducing an immunological response against a cell expressing a breast cancer associated antigen, wherein the breast cancer associated antigen is mucin and/or carcinoembryonic antigen, in a human, wherein the method comprises:
- (a) selecting a human having breast cancer,
- (b) administering to the individual a first poxvirus vector comprising SEQ ID NO:1 and SEQ ID NO:3 and DNA sequences encoding ICAM-1, LFA-3, and B7.1, and
- (c) at regular intervals thereafter administering at least a second poxvirus vector comprising SEQ ID NO:1 and SEQ ID NO:3 and DNA sequences encoding ICAM-1, LFA-3, and B7.1,
- such that an immunological response against the cell expressing the breast cancer associated antigen is induced in the individual.
Dependencies are inferred from the claim text.