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US 8,933,016 B2Granted
Metallodrugs having improved pharmacological properties and methods of manufacture and use thereof
AssigneeMetallopharm LLC
InventorsJames A. Cowan, Ada S. Cowan
Life of this patent
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Abstract
It is an object of the present invention to provide antimicrobial metallodrugs comprising an antimicrobial peptide (“AMP”) and/or an antibiotic covalently bound to a metal binding moiety. These metallodrugs combine a metal binding domain which typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, with a member of a diverse class of antimicrobial agents currently validated in preclinical and clinical settings for the treatment of a broad spectrum of pathogenic organisms.
Claims22
An antimicrobial composition, comprising:
- a first moiety which is (i) an antimicrobial peptide (“AMP”), or peptide that binds to a pathogenic target, the sequence of which is between 6 and 100 amino acids, is net positively charged, and is amphipathic, (ii) an antibiotic, or (iii) a conjugate comprising an AMP, or peptide that binds to a pathogenic target, and an antibiotic;
- and
- a second moiety which is a metal binding moiety selected from the group consisting of a peptide motif, a cyclam, a cyclen, and a non-porphyrin macrocyclic chelating agent,
- wherein the first moiety and the second moiety are covalently linked to form a complex, wherein the second moiety is heterologous to the first moiety, wherein the first moiety and the second moiety act separately, with distinct functions, in such a way that the second moiety enhances the antimicrobial effects of the first moiety, and wherein the first moiety promotes uptake of the complex into a target cell or organelle.
1 more element
Dependencies are inferred from the claim text.