Calcium-mediated effects of coral and methods of use thereof
AssigneeBen-Gurion University of the Negev Research and Development Authority
InventorRazi Vago
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Abstract
This invention is directed to coral scaffolds seeded with precursor cells in culture in the presence of a chelator and uses thereof in inducing or enhancing bone and/or cartilage formation in a subject, and kits related thereto. This invention is also directed to use of cadherin-upregulating coral for treating cancer or inhibiting cancer progression. This invention is also directed to use of aragonite or calcite-producing species for in vivo calcium release, and its application to the treatment of skin diseases, disorders or conditions.
Claims31
A method of inducing or enhancing bone or cartilage formation or a combination thereof in a subject comprising administering to said subject a composition comprising:
- coral seeded with precursor cells selected from mesenchymal stem cells, chondrocytes and osteoblasts, wherein said coral is seeded with said cells in culture in the presence of a chelator for a period of time sufficient to seed said cells in said coral and wherein the cell density of said cells is higher than that of the same type of coral seeded with the same type of cells in culture in the absence of the chelator.
A method of inducing or enhancing bone or cartilage formation or a combination thereof in a subject comprising:
- seeding coral with precursor cells selected from mesenchymal stem cells, chondrocytes and osteoblasts,
- culturing the seeded coral in the presence of a chelator for not more than 72hours,
- and administering to said subject a composition comprising said cultured seeded coral.
Dependencies are inferred from the claim text.