Treatment of back pain by injection of microparticles of dexamethasone acetate and a polymer
AssigneeSpineThera
InventorJeff Missling
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Abstract
A method for the treatment of back pain by injection of an injectable flowable composition in the epidural space, wherein the composition is composed of microparticles of dexamethasone acetate and a polymer, are disclosed.
Claims10
A method for the treatment of back pain, the method comprising injecting no more than once per about 12 weeks an injectable, flowable composition having a total volume of less than about 5 mL into the epidural space, the composition comprising:
- (a) microparticles comprising dexamethasone acetate and a polymer, wherein the surface of the microparticles are hydrophilic, the microparticles have a d50 of about 2 μm to about 5 μm, the polymer comprises a block copolymer of lactic acid and glycolic acid (PLGA) and polyethylene glycol (PEG), and the active pharmaceutical ingredient is present in a weight of up to about 40% the weight of the polymer;
- and
- (b) a hydrophilic, aqueous liquid carrier vehicle;
- wherein the microparticles are substantially miscible to dispersible in the liquid carrier vehicle.
A method for the treatment of back pain, the method comprising injecting no more than once per about 12 weeks an injectable, flowable composition having a total volume of less than about 5 mL into the epidural space, the composition comprising:
- (a) microparticles comprising dexamethasone acetate and a polymer, wherein the surface of the microparticles are hydrophilic, the microparticles have a d90 of less than about 7 μm, the polymer comprises a block copolymer of lactic acid and glycolic acid (PLGA) and polyethylene glycol (PEG), and the active pharmaceutical ingredient is present in a weight of up to about 40% the weight of the polymer;
- and
- (b) a hydrophilic, aqueous liquid carrier vehicle;
- wherein the microparticles are substantially miscible to dispersible in the liquid carrier vehicle.
A method for the treatment of back pain, the method comprising injecting no more than once per about 12 weeks an injectable, flowable composition having a total volume of less than about 5 mL into the epidural space, the composition comprising:
- (a) microparticles comprising dexamethasone acetate and a polymer, wherein the surface of the microparticles are hydrophilic, the microparticles have a d90 of less than about 5 μm, the polymer comprises a block copolymer of lactic acid and glycolic acid (PLGA) and polyethylene glycol (PEG), and the active pharmaceutical ingredient is present in a weight of up to about 40% the weight of the polymer;
- and
- (b) a hydrophilic, aqueous liquid carrier vehicle;
- wherein the microparticles are substantially miscible to dispersible in the liquid carrier vehicle.
Dependencies are inferred from the claim text.