Combination of DNA repair inhibition with bendamustine or gemcitabine in the treatment of cancer
AssigneeInstitute For Cancer Research
InventorsAlfonso Bellacosa, Timothy Yen, Neil Beeharry, Mitchell Smith
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Abstract
The invention provides methods for enhancing the cytotoxicity of DNA damage in cancer cells that express thymine DNA glycosylase, and treating tumors accordingly. The methods comprise inhibiting the expression or biologic activity of thymine DNA glycosylase, and inducing DNA damage in the cancer cells. DNA damage may be induced by administration of bendamustine or gemcitabine to the cancer cells.
Claims8
A method for treating a tumor that expresses thymine DNA glycosylase, comprising transforming cells in the tumor with an inhibitory RNA molecule comprising the nucleic acid sequence of SEQ ID NO:
- 2, and inducing DNA damage in the cells.
Dependencies are inferred from the claim text.