5′ phosphate mimics
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsMuthiah Manoharan, Kallanthottathil G. Rajeev, Marija Prhavc, Ivan Zlatev
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Abstract
The present invention provides nucleosides and oligonucleotides comprising a 5′ phosphate mimics of formula (IVc) or (Vc). One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such dinucleotide of formula (Ia). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
Claims14
An oligonucleotide comprising a nucleoside represented by:
Dependencies are inferred from the claim text.