Modulations of protease activated receptors

A compound of the formula (I):

• wherein
• R1 is —C(O)R8;
• R8 is a 5- or 6-membered unsaturated heterocyclic ring comprising 1 to 3 heteroatoms selected from N and O, optionally substituted with one or more substituents selected from alkyl, alkoxy, amine, aminoalkyl, amidoalkyl, halo, hydroxy, trihaloalkyl, trihaloalkoxy, and phenyl, wherein the phenyl group is optionally substituted with 1 to 3 substituents selected from alkyl, alkoxy, hydroxy, halo, nitro, trihaloalkyl, and trihaloalkoxy;
• R2 is an aromatic or aliphatic C3-C8cyclic group or C3-C8heterocyclic group comprising 1 to 3 heteroatoms selected from N and O, wherein the C3-C8cyclic group or C3-C8heterocyclic group is optionally substituted with one or more substituents selected from alkyl, amine, and hydroxy, or the cyclic group or heterocyclic group is fused with an optionally substituted aromatic or aliphatic C3-C8cyclic group or C3-C8heterocyclic group;
• R3 is hydrogen or C1-C6alkyl;
• R4 is hydrogen, C1-C6alkyl, aminoalkyl, or amidoalkyl;
• R5 is a benzyl group optionally substituted with alkyl, aminoalkyl, alkoxy, C4—C7heterocycle, hydroxy, halo, nitro, dioxalane, trihaloalkyl, trihaloalkoxy or —C(O)NHCHR9R10;
• R9 is —C(O)NH2;
• and
• R10 is a C2-C5aminoalkyl;
• or
• R4 and R5 combined, together with the nitrogen to which they are attached, form piperidine, optionally substituted but not fused with a group selected from phenyl, benzyl, aminoaryl, amidoalkyl or a heterocycle, or piperidine is fused with an aromatic or aliphatic C3-C8heterocyclic group;
• wherein the phenyl, benzyl, aminoaryl, heterocycle or fused aromatic or aliphatic C3-C8heterocyclic group may be further substituted with 1 to 3 substituents selected from alkyl, alkylsulfonyl, alkoxy, aminoalkyl, aminoaryl, amidoalkyl, arylamine, hydroxy, halo, nitro, oxo, optionally substituted phenyl, optionally substituted piperidine, dioxalane, trihaloalkyl, and trihaloalkoxy;
• or
• the fused aromatic or aliphatic C3-C8heterocyclic group is fused with an additional C6-C10cyclic or C6-C10heterocyclic group;
• R6 is hydrogen or C1-C6alkyl;
• R7 is C1-C6alkyl, amino, hydroxy, alkoxy, aminoalkyl, amidoalkyl, saturated or unsaturated cycloalkyl, or heterocycle;
• or
• a salt thereof.