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US 8,921,335 B2Granted
Oral delivery of nucleic acid-based gene interfering agents by Salmonella
AssigneeThe Regents of the University of California
InventorsHao Gong, Yong Bai, Sangwei Lu, Fenyong Liu
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Abstract
the Present Invention Provides Vectors, Including a Novel Attenuated Strain of Salmonella, for Efficient Gene Transfer into an Animal, e.g. a Mammalian Host.
Claims7
A method of inhibiting cytomegalovirus replication, the method comprising:
- contacting a cell infected with the cytomegalovirus with an attenuated Salmonella having a deletion in ssrA/B, and comprising a plasmid construct encoding a targeted M1GS ribozyme that cleaves cytomegalovirus mRNA essential for replication, wherein viral replication is inhibited.
A method of inhibiting cytomegalovirus replication in an individual, the method comprising:
- orally administering to the individual an attenuated Salmonella having a deletion in ssrA/B, and comprising a plasmid construct encoding a M1GS ribozyme targeted to a cytomegalovirus mRNA essential for replication,
- wherein viral replication is reduced by at least 2,500-fold.
Dependencies are inferred from the claim text.