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US 8,920,812 B2Granted
Chimeric RSV-F polypeptide and lentivirus or alpha-retrovirus Gag-based VLPS
AssigneeTakeda Vaccines, Inc.
InventorJoel R. Haynes
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Abstract
The present invention relates to chimeric RSV-F polypeptide and lentivirus or alpha-retrovirus GAG-based virus-like particles (VLPs). The present invention also includes methods of making and using such chimeric VLPs. In certain embodiments, the GAG polypeptide of the chimeric VLPs comprises an HIV or ALV GAG polypeptide.
Claims24
A chimeric virus-like particle comprising a lentivirus or an alpha-retrovirus Gag polypeptide and a respiratory syncytial virus F polypeptide.
A method for producing a chimeric virus-like particle, comprising:
- (a) providing one or more expression vectors together which express a lentivirus or an alpha-retrovirus Gag polypeptide and a respiratory syncytial virus F polypeptide;
- (b) introducing the one or more expression vectors into a eukaryotic cell in a media;
- and
- (c) expressing the Gag polypeptide and the respiratory syncytial virus F polypeptide to produce the chimeric virus-like particle.
1 more element
Dependencies are inferred from the claim text.