Vault complexes for cytokine delivery
AssigneesThe Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs
InventorsLeonard H. Rome, Valerie A. Kickhoefer, Steven M. Dubinett, Sherven Sharma, Upendra K. Kar
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Abstract
The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.
Claims17
A composition comprising a vault complex comprising a major vault protein and a fusion protein comprising a cytokine and a vault targeting domain, wherein the vault targeting domain is a vault poly ADP-ribose polymerase (VPARP) sequence or a portion thereof that interacts with the major vault protein, or a telomerase/vault associated protein 1 (TEP 1) sequence or a portion thereof that interacts with the major vault protein, wherein the fusion protein is non-covalently associated with the vault complex.
Dependencies are inferred from the claim text.