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US 8,920,801 B2Granted
Methods and compositions for increasing arylsulfatase A activity in the CNS
AssigneeArmaGen Technologies, Inc.
InventorsWilliam M. Pardridge, Ruben J. Boado
Life of this patent
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Abstract
Provided herein are methods and compositions for treating a subject suffering from a deficiency in arylsulfatase A in the CNS. The methods include systemic administration of a bifunctional fusion antibody comprising an antibody to a human insulin receptor and an arylsulfatase A.
Claims20
A fusion antibody comprising:
- (a) an arylsulfatase A (ASA) monomer, and (b) a single-chain antibody;
- wherein the fusion antibody crosses the blood brain barrier (BBB).
A fusion antibody comprising:
- (a) a fusion protein comprising the amino acid sequences of an immunoglobulin light chain and an arylsulfatase A monomer, and (b) an immunoglobulin heavy chain;
- wherein the fusion antibody crosses the blood brain barrier (BBB), wherein the amino acid sequence of the arylsulfatase A is covalently linked to the carboxy terminus of the amino acid sequence of the immunoglobulin light chain.
Dependencies are inferred from the claim text.